Can Zoloft or Lexapro be taken while on Depakote?
Hello, and thanks for your question.
If you are taking Depakote, this indicates you have likely been diagnosed with bipolar disorder. In bipolar disorder, antidepressants such as Zoloft or Lexapro have not been shown in large scale clinical trials to be more effective than placebo. I would encourage a medication such as Seroquel, which is approved for bipolar depression and can also help with anxiety.
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