Question: I take 1 MG Xanax XR twice daily and 10 MG Ambien nightly to sleep. I also have .5 regular Xanax up to twice per day as needed for panic attacks. My Doctor has just prescribed Wellbutrin for my anxiety and depression. I haven't taken it yet because I read there's a conflict taking these drugs together. Let me give you some background. My son was electrocuted in 2009 and I lived in a burn unit for 7 months -burns 67% of his body and double below the knee amputations. He lived and had a total of 37 surgeries over a 3 year period for the burns (grafting) and leg corrective surgery to be fitted for prosthetics. I was on 3 mg of Xanax XR twice per day, Zoloft, Cymbalta, Buspar and Lunesta for 3 years after his accident. I was diagnosed with severe PTSD. I eventually weaned off all of the meds in 2013. In the past 2 years I started the Xanax again because my anxiety is off the charts. Eventually the Ambien was added because I wasn't sleeping. I'm back to the point where I need an antidepressant and I've heard good things about Wellbutrin, especially no weight gain. I've seen the same PCP for the past 20+ years. Psychiatry is very limited in my area - 2 doctors and months to get an appt. Is this a safe combination. I also take estrodial 1 mg - had a total hysterectomy in 2015 and .75 mcg of Synthroid- Thyroid removal in 2005. I'm not overweight, I do not have high blood pressure and my cholesterol, etc is perfect. I just turned 50 in August and I try to stay active but I am severely depressed and it isn't getting better, only worse.