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Dr. Andrew Rynne

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Can Tyrosine cause tolerance by using it?

Answered by
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Dr. Suma Parinam

General & Family Physician

Practicing since :2008

Answered : 1704 Questions

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Posted on Fri, 8 Jun 2018 in Medicines and Side Effects
Question: hey guys,

I am wondering if i use the amino acids trytophan or tyrosine will i develop a tolerance by using them. i am getting mixed responses from articles online and peoples reviews on the supplement.

are the supplements safe to take in the long term for mild anxiety and depression and just as a supplement for my own well being as if i were going to take a vitamin or protein shake?

are there any dangers to using them at all that i should know about..?

thankyou
doctor
Answered by Dr. Suma Parinam 15 minutes later
Brief Answer:
Avoid aminoacid supplements unless proven to be deficient

Detailed Answer:
Hi,

You are talking about essential amino acid supplement tyrosine or tryptophan. Unless proven deficient I would avoid using them to my patients. In that matter any external supplements are not found to be effective unless deficient. Moreover these aminoacids tryptophan are not strongly effective / positively effective in any proven illness, they are possibly effective in premenopausal disorder or when you are quitting smoking. Else they have no proven uses.
So when there is no strong benefit why should one use it? I still prefer a balanced diet with adequate quality protein content that can give you all the neurotransmitter substrates needed.

So this is my strong opinion.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Suma Parinam 19 minutes later
can ssri antidepressant medication cause a defficiency if one chose to take less of that medication? if this were the case, would i benefit from supplementing on tryptophan or tyrosine to help aid in recovery?
doctor
Answered by Dr. Suma Parinam 11 minutes later
Brief Answer:
Studies about tryptophan supplements with chronic ssri medication

Detailed Answer:
SSRI anti depressant medication was believed to cause lower intraneuronal serotonin levels but only in subjects that have a rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5 hydroxy tryptophan synthesis. But this kind of mutations are very rare. Over that further studies have to be done on supplementing tryptophan along with SSRI's if it can improve peripheral serotonin levels and if it can be approved for clinical practice.

So for now there is no robust evidence that proves supplementation helps aid in recovery.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Suma Parinam 1 hour later
what would you recommend to your patients, who want to come off this medication after chronic use?
I tried once to get off my ssri medication. with that first experience i lasted 6 months before i was forced to use them again as my mental health had declined to the point where i could not work or socialise with friends or family for a period of time until the medication was taken back again.
i suffered from increased emptional sensitivity, inceased feelings of negativity, increased levels of aggessiveness, anger, nervousness, depression, anxiety. i felt like inwas drunk for 6 months straight. if i could describe it, it felt like i was i had a drunken hang over, with the mental control of a toddler. i jad memory problems..all sorts of problems
Im doing this again. ive tapered over a year to reach half to of my medication. this is as far as ive manged to go after a year. sinve then ive suffered from ibs, acid reflux, nerve pain in the body, increased anxiety, depression, anger, panic attacks and all the other symptoms i did the first time that i went off this medication.
even with a slow taper, a good diet, pleanty of excersize and meditation, i could not go any further.
in your opinion is it better to stay on this medication for life? or to replace them with amino acid? what is better? what would u recommend a patient who wants to come off their ssri medication after chronic use?
doctor
Answered by Dr. Suma Parinam 2 hours later
Brief Answer:
Long term SSRI

Detailed Answer:
in your opinion is it better to stay on this medication for life? or to replace them with amino acid? what is better?
== There is no real reason to put extra supplements while on SSRI's, I would suggest to stick to quality diet with all colors (7 in number) in your plate. I would continue to support medication for life unless the benefits are completely off.

what would u recommend a patient who wants to come off their ssri medication after chronic use?
=== In our setting a chronic patient with depression is managed by Psychiatrist with follow up to GP. The GP would not really meddle with doses but check for side effects. So decision to call of the medication has to be discussed by a patient with Psychiatrist.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Suma Parinam 22 hours later
can medication for life not be damaging? if forced to stop taking this medication what f the consequences then?i appreciate your point of view and will heavily take this into consideration as using supplements such as tyrosine and tryptophan may be a risk not worth taking. however ill have to speak with my doctor and a psychiatrist to make this decision final. the bottom line is getting off medication safely and returning to a normal life would be much better, there is no reason to not try to get off medication if can be done. the biggest risk is here above all else is for me, the health risk on mental health if i ever an in a situation where i have to get off my medication. what do i do then? id be helpless like i was last time. thankyou for your answer. id rather your honesty, then one i want to hear. thanks.
doctor
Answered by Dr. Suma Parinam 23 hours later
Brief Answer:
Long term medications.

Detailed Answer:
The medication if properly given by your doctor and taken by you as per the schedule would not last for long. The medication would be titrated according to the needs. Moreover there would be newer medications with lesser side effects in clinical trials. So do not worry about long term medications and its side effects.

HOPE, have this for better future. TRUST, in your doctors. SPIRIT, let it be with you.

If you do not have more queries please close and rate my answer.


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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