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Can Hydrocodone-acetaminophen and Duloxetine be taken together?

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Posted on Mon, 3 Oct 2016
Question: can I take hydrocone-acetam 7.5-325mg with duloxetine 20mg ? if so, what effects should I watch for?
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Answered by Dr. Muhammad Ali Rauf (1 hour later)
Brief Answer:
Strong interaction can occur; should be taken under supervision

Detailed Answer:
Hello

Thank You for contacting HCM. My name is Dr Muhammad Ali Rauf & i will look into your problem.

I have gone through your query and would try to help you in the best possible way. Duloxetine will increase the levels/effects of hydrocodone by affecting its metabolism. As a result there will be increased chances of dizziness, drowsiness, light headedness, addiction, respiratory depression& GI effects like constipation & vomiting. So its not recommended to use these two medicines together WITHOUT direct supervision of a treating doctor.


Hope I have answered your query. If you have any further questions I will be happy to help if not then don't forget to close the discussion and rate it.
Wishing you good health !!
Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Follow up: Dr. Muhammad Ali Rauf (14 hours later)
Thank you for your timely reply. Your reply to my question was as I expected, eg; drug interactions. Mahalo, XXXXXXX XXXXXXX
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Answered by Dr. Muhammad Ali Rauf (3 hours later)
Brief Answer:
You are welcome

Detailed Answer:
Hello

You are most welcome. I'll be available 24/ for if you ever need assistance. Don't forget to close the discussion and rate it.

Thankyou!

Above answer was peer-reviewed by : Dr. Priyanka G Raj
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Answered by
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Dr. Muhammad Ali Rauf

General & Family Physician

Practicing since :2013

Answered : 1313 Questions

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Can Hydrocodone-acetaminophen and Duloxetine be taken together?

Brief Answer: Strong interaction can occur; should be taken under supervision Detailed Answer: Hello Thank You for contacting HCM. My name is Dr Muhammad Ali Rauf & i will look into your problem. I have gone through your query and would try to help you in the best possible way. Duloxetine will increase the levels/effects of hydrocodone by affecting its metabolism. As a result there will be increased chances of dizziness, drowsiness, light headedness, addiction, respiratory depression& GI effects like constipation & vomiting. So its not recommended to use these two medicines together WITHOUT direct supervision of a treating doctor. Hope I have answered your query. If you have any further questions I will be happy to help if not then don't forget to close the discussion and rate it. Wishing you good health !!