Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
176 Doctors are Online

Can Azithromycin and Doxcycline be combinedly taken for lyme treatment?

User rating for this question
Very Good
Answered by

General & Family Physician
Practicing since : 2004
Answered : 1777 Questions
Im currently being treated for Lyme. I have taken Doxcycline for 2 1/2 weeks, but my doctor now wants me to take only azithromycin. From what Ive researched it seems the two together could actually be pretty effective as they attack the bacteria's ability to synthesis proteins differently. My question is Would it be smart & safe to finish off the original suggested 4 week course of Doxcycline(100mg 2 D) with the now additional azithromycin(250 mg 1 d)? Or should I discontinue and switch directly to only taking the azithromycin?
Posted Wed, 6 Aug 2014 in Infections
Answered by Dr. Chakravarthy Mazumdar 7 hours later
Brief Answer:
Finish off the original Doxycycline for 3 weeks

Detailed Answer:

The antibiotic of choice for Lyme disease depends on the symptoms or manifestations of the disease. To be honest I have not read Azithromycin as a first line drug unless there is Penicillin allergy documented.

1) Stage 1: rash we treat with either Oral Doxycycline or amoxicillin for 3 weeks
2) Stage 2: Neurological problem (meningitis, Bells palsy) Intravenous ceftriaxone (Penicillin group)
3) Stage 3: Cardiac heart block again IV ceftriaxone
4) Arthralgia, we go with doxycycline for 3 weeks.

I agree with the school of thought that both Doxy and Azithro have different class of action but multiple antibiotics at the same time is the last bullet. If the Doxycillin does not help in 3 weeks there is no point in going ahead with it. It is better to switch to alternative therapy.

Since you completed 2 1/2 weeks, continue for another half week and stop it and switch. With that point of view you can go ahead with your doctor's treatment with Azithromycin.

Hope this helps.
Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+

The user accepted the expert's answer

Ask an Internal Med Specialist

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor