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Can Aspirin Cause Renal Failure?

Posted on Tue, 29 Sep 2015

Question: My mother aged 86 was admitted to ICU of a hospital in New XXXXXXX for high urea (208) and Creatinine (~2.0) which was caused by diuretics given for swelling on her body. Her blood thinning medication (ecosprin) was stopped and was probably not restarted even when her urea and creatinine levels started coming down. After about 10 days she was on verge of discharge when she suddenly had trouble eating and became extremely drowsy. Investigations revealed multiple small infarcts in her brain which kept deteriorating her condition. I wish to know whether stopping the blood thinning medication was required under the circumstances or should it have been continued?

Answered by Dr. Ajay Panwar (3 hours later)

Brief Answer:
It has no defined guidelines.

Detailed Answer:
Hi XXXX
Thanks for being on healthcaremagic.
I am Dr.Ajay Panwar,a neurologist,here to answer your query.

Use of aspirin in renal failure in patients with ischemic stroke has a slight controversy around it.Although,ischemic stroke(infarcts) is an absolute indication for ecosprin but due to its potential to cause kidney damage,some of the treating physicians may stop it for the time period when the renal functions are deranged.On the other hand,some may continue to give it considering the fact that infarct is an absolute indication for stroke.
So,the decisions may vary according to the treating physicians.It has no well defined guidelines.

If you have any further questions,I shall be glad to answer.

Regards
Dr.Ajay Panwar,
MD,DM(Neurology)

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Ajay Panwar (14 hours later)

Thank you Dr Panwar. My mother kept deteriorating and was on Riles tube, her speaking was lost slowly, she would open her eyes only with aggressive efforts and subsequently lost her limb moving ability in next 8-10 days. After about a week she was also diagnosed with urine infection (K Pneumonae). She subsequently had a small/minor bleeding in her brain because the doctors put her on "Eliquis", Syndopa (which was later stopped). However after about 12 days we were told that she had developed pneumonia and they started treatment for suspected septicemia. We lost our mother within 24 hrs due to multiple arrests. Later we came to know that K pneumonae infection, which was in her urine, also went to her blood and was resistant to all antibiotics. I strongly feel that the initial negligence took her life. Kindly guide us on this.

Answered by Dr. Ajay Panwar (42 minutes later)

Brief Answer:
Recovery at her age was not easy.

Detailed Answer:
Hi XXXX,
Thanks for being in follow-up.

I am not in a position to say that the doctors were negligent.I was not facing the clinical challenge over there.Only the doctors who were treating the patient would know that how was the clinical situation.Prognosis at 86 years of age,in a patient of complicated urinary tract infection,will not be good in theoretical terms,in any part of the world.

If you have any further questions,I shall be glad to answer.

Regards
Dr.Ajay Panwar,
MD,DM(Neurology)

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar