Are ALP levels of 489 and high globulin levels a cause for concern?
Electrophoresis and bone marrow biopsy if need be
Welcome to health care magic, thanks for posting your query.
ALP is generally present in all the cells all over body but mainly present in liver, bones, bile duct, intestinal lining (mucosa), kidney.
High ALP in backdrop of normal bilirubin, AST and ALT might be related to number of conditions such as:-
-Biliary duct obstruction or gall bladder stone
-Intestinal disease like coeliac disease.
-Certain blood cancer like lymphoma or leukemia
In your case, ALP is not so high(489) along with high globulin, so you need not to worry much, I would advise you to go for further evaluation to find out underlying cause.
For further investigation I would advise you for CBC, electrophoresis, thyroid function test, serum calcium, ultrasound abdomen and pelvis to look for liver, gall bladder, billiary tree and kidney and if need be Bone marrow biopsy.
Meanwhile continue with present medicines you are taking Silymarin, urseo and lecithin.
Complete avoidance of alcohol and smoking is advisable.
Hope I could answer your question, Please feel free to ask for further assistance, I will be happy to help you.
below is my LFT report for your convenience
SGOT - 26.9 IU/L
SGPT - 19.0 IU/L
Bilrubin Total - 0.71 mg/dl
Bilrubin Direct - 0.20 mg/dl
Bilrubin Indirect- 0.51 mg/dl
Alkaline Pho.4 - 489 IU/L
Total Protein - 8.1 gm/dl
Albumin - 3.3 gm/dl
Globulin - 4.8 gm/dl
Am i prone to any major liver disease ???, please suggest..
Last year (feb/2015) i underwent varicocele surgery which surprised me and my doc as varicocele advanced to leve II stage without showing any body sympotms (during varicocele surgey my appendicitis was removed on its excess swelling images), and thats the main worry for me as my body shows any sympotoms very late and later get diagnosed for major.
at now i am advised to take ureso & sillymarin 150mg & 70mg respectively with lecithin Twice a day for next 2-3 month, should i contiune with medicine or should seek advice to any specialist
i heard that sillymarin intake gets used to the body so it should be taken for 2 weeks only later give gap of 2 weeks and so on.
i am staying very far from urban places and maintaing myself away from alchol from last 2 months, i totally stopped smoking 2 years ago, at present chewing tobacco with betelnuts, does intake of tobbaco affect/damage liver function
Electrophoresis and ultrasound abdomen is advisable to start with.
Welcome again and thanks for all the details.
Since globulin level is also high with elevated level of ALP so I would advise you to go for all the tests (mainly electrophoresis and ultrasound abdomen), I have advised you in previous reply to rule out/early diagnosis of any other related condition.
Silymarin is a herbal product which has antioxidants and anti inflammatory properties, so you can take it which will help by improving efficiency of liver function.
it's not addictive but it's better to avoid high doses and you can take it regularly.
Since you used to smoke and drink so high ALP might be related to residual liver damage, However I would advise you to go for electrophoresis and ultrasound abdomen for further evaluation.
Hope I could answer your question, Please feel free to ask for further clarification, I will happily answer you.
what I had done in past had surely damaged the liver cell I hope I can recover it by medication and proper food diet avoiding harmful habits & substance,
Awaited for your suggestions
it may take 6 months to a year
when you go for this reports, you can see your family physician or haematologist according to your convenience.
Residual damge could be permanent or reversible which can be assessed by ultrasound and further investigation
Reversible damage can be corrected by life style modification and quitting smoking and alcohol, it may take 6 months to a year to get back to normal or decrease the severity of damage.
Hope I could answer your question, Please feel free to ask if you have any more queries.I will gladly answer you.
wishing you good health.