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Suggest side effects of steroid treatment - Online Doctor Chats

Date : 19-Apr-2014
User rating for this question
Very Good Posted in: Medicines and Side Effects
Answered by

General & Family Physician
Practicing since : 2005
Answered : 2408 Questions
Doctor:hi
User:Hi. I took some steroid treatment in early puberty to increase my height. i have learned steroids can affect brain too. After stopping the treatment, my test didnt return to normal because i progressed through puberty. So there couldnt have been downregulation on brain because test never went back to pre-treatment level. In a way, does this mean the effects of steroids have been sustained by my increasing endogonous steroid(testosterone) production? Please advise
Doctor:re
User:hello again
User:I took some steroid treatment in early puberty to increase my height. i have learned steroids can affect brain too. After stopping the treatment, my test didnt return to normal because i progressed through puberty. So there couldnt have been downregulation on brain because test never went back to pre-treatment level. In a way, does this mean the effects of steroids have been sustained by my increasing endogonous steroid(testosterone) production? Please advise
Doctor:Hello
User:??
Doctor:If you were advised to take steroids by your doctor
Doctor:that means you had low testosterone levels
User:in beginning of puberty yes
Doctor:What that means is, since you had low testosterone levels before your treatment, the treatment actually corrected the problem
Doctor:But if the dosage of testosterone was significantly higher than required
User:NO
User:from the beginning
Doctor:I don't understand, what do you mean by NO?
User:can i have neurologist?
User:i want to know about effects on brain
Doctor:I am sorry, we do not have neurologists or any specialists available for chats
Doctor:I am coming to that
User:Ok
Doctor:You have to understand the basics first
Doctor:I have seen your questions many times
Doctor:I know that you are worried about it
Doctor:I completely understand your worry
User:Thanks
Doctor:Do you agree with me that, you had low testosterone levels before you started treatment
Doctor:?
User:of course - i was a child
User:pre puberty
Doctor:Okay
Doctor:do you mean to say that your testosterone levels were normal for your age that time?
User:but as treatment went on, endogonous steroids began progressing
User:yes
Doctor:Okay
Doctor:was this treatment advised to you by a doctor?
User:Yes
Doctor:okay
Doctor:Anyways, as I had told you in our previous chat, the levels of testosterone change as per our age
Doctor:so it is quite normal for the testosterone levels to increase as you approach puberty
Doctor:and this testosterone does have effects on all organs
Doctor:including the brain
User:Can ihave DR XXXXXXX
Doctor:higher testosterone levels usually cause more aggressive behavioral changes
User:oh ok
Doctor:I am sorry, Dr. XXXXXXX is on leave today and tomorrow
User:please continue...
User:ok please continue...
Doctor:Not so much on the adrenal gland
Doctor:But there is another mechanism called feedback mechanism
User:i know all this ....
User:please advise as per my question
User:i will write again....
Doctor:what this does is, if you are taking exogenous steroids, the endogenous steroid production will drop
Doctor:I am answering your question
Doctor:You will have to be a little more patient
Doctor:I am trying to make it easier for you to understand
User:During treatment , the steroid causes upregulation effects on brain....
Doctor:we take years to understand this, so it is impossible to give you all that information, but I am trying to condense and make it as easily understandable as I can
User:because i was in prepubertal age, towards end of treatment, my endogonous steroids began increasing. This means the previous low level will never be seen again
Doctor:Can you be specific about the upregulation
Doctor:because testosterone has very complex mechanisms
User:any upregulation effects...creating new circuits?
Doctor:it is not universal upregulation of all functions of the brain
Doctor:No, it does not cause an upregulation of all functions of the brain
User:upregulating new circuits
Doctor:What do you mean by new circuits?
User:new connections
User:programming new circuits
User:etc
Doctor:Not really
User:Wy
User:Why
Doctor:that is basically genetically determined
User:Ok...
User:So what in the brain does it upregulate...? And since towards end of treatment endogonous steroids is increasing , does this mean the upregulation is sustained (from steroids treatment time) ?
User:?
Doctor:No
Doctor:I am sorry, I had a momentary internet loss
Doctor:Testosterone has specific functions
User:yes...
Doctor:that is, it only reinforces the maleness of some of the functions of the brain
Doctor:It doesn't cause universal upregulation of all functions of the brain
Doctor:it does not affect your intelligence
Doctor:or your logic
Doctor:or language capabilities
User:yes...
Doctor:It only makes some changes in the emotional functions
Doctor:and since the release of endogenous testosterone is controlled by the feedback mechanism
Doctor:taking exogenous testosterone prevents endogenous testosterone release
Doctor:whatever effects you had very basically because of the exegenous testosterone you were taking
Doctor:But once you stop the exogenous testosterone, then the body will start producing the required amounts of testosterone
Doctor:as I have said earlier, testosterone levels increase as you grow to become an adult
Doctor:the levels after you have become an adult will always be higher than your childhood levels
Doctor:This is how it works
Doctor:there is no other way for this to happen
User:Yes but the exogonous testosterone effects would be sustained by endogonous testosterone as treatment ends...true or false?
Doctor:True and false
User:so the reinforcing of male behabiour by treatment would be sustained by endogonous test
User:thus changes are permanent
Doctor:once your brain matures, then testosterone will stop having any noticeable changes other than that happened while you were growing up to be an adult
Doctor:Yes
Doctor:The reinforcing of male behaviour will be maintained by the endogenous testosterone
Doctor:The changes may be permanent
Doctor:unless you get a sex reassigning surgery
Doctor:if the testosterone levels don't remain as high as they should in normal males, then you will start seeing more feminine behaviours
Doctor:I hope this time I was able to answer your question
Doctor:Thanks for consulting me here
Doctor:have a good day ahead
Doctor:bye
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