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Query about damaging of liver due to excessive paracetamol - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Excellent Posted in: Medicines and Side Effects
Answered by

General & Family Physician
Practicing since : 2004
Answered : 40 Questions
User :   I am suffering from alcoholic hepatitis and the doctor says, i may also be in the early stages of cirrhosis. I have completely stopped alcohol now, but I do have ascitis for which I am taking dirutics. For pain I take spasmp proxyvon and but max 5 capsules in 24 hours (i.e. 2 gms of acetiminaphon). Is this 2gms of paracetamol harm my live further ?? I know the safe limit is 4 gms in 24 hours.
Doctor :   Hi
User :   hi
User :   u see my problem above
Doctor :   I am reading , plz wait
Doctor :   Yes
Doctor :   Paracetamol is metabolized in the liver purely
User :   read ?
User :   ok
User :   but if eat it within safe limit and dont drink, it will still harm ?
Doctor :   Even though safe limit is 4gm in normal patients, the safer dose might be very less in patients with liver damage
User :   how much ?
Doctor :   Let me search safe dose of paracetamol in liver disease
User :   thanx
Doctor :   in one study 1 gm paracetamol t. i. d does not resulted in any signs of hepatotoxicity
Doctor :   FDA recommended dose is max to 3200mg
User :   3.2 gms max in liver disease?
User :   even without drinking
Doctor :   That is was the results of clinical research on liver cirrhosis patients
Doctor :   The Alcohol drinking was not included in the study
User :   so what should i follow ? 1gm or FDA's 3.2 gms
Doctor :   SO in patients with liver disease,the max safe dose is 3200mg
Doctor :   You can follow the FDA recommendations
User :   even if taken for a long period and everyday ?
Doctor :   If the spasms/pains are controlled with less dosages that is fine
Doctor :   Yes
Doctor :   even if taken on chronic basis there is no toxicity in studies
User :   ok ! thanks
Doctor :   You can read short article
Doctor :   Thank you for consulting
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