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Invasive ductal carcinoma of the right breast - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: Breast Cancer
Answered by

General & Family Physician
Practicing since : 2005
Answered : 2408 Questions
User :   I'm 45 with Invasive ductal carcinoma right breast and had bilateral mastectomy with reconstruction. negative sentinel nodes, 8 removed just in case. PET scan MRI all negative for adenopathy or any mets. tumor was 3cm but reduced inhalf after core needle biopsy. ER/PR negative her2 positive so I will be on herceptin. Lab test showed p53/ki-67 high at 90%, moderately differentiated grade 2 Nottingham. I think it was caught on time. My question is regarding the p53/k--67. I know it means a fast growing tumor(now gone) and I also read that is common on most cancers and in some literature it sounds like very bad but studies do not specify the treatments done. Would this have any impact on the type of chemo/prognosis? or the fact that both breasts are gone, node negative, negative pet/mri and tumor markers and future herceptin/chemo brings hope and avoid recurrence? thanks
Doctor :   hello
Doctor :   i am DR here
Doctor :   give me a min
Doctor :   let me read your query
User :   ok
Doctor :   well you are right in your approach
Doctor :   its true that with a negative pet and mri and with a complete course of chemo . the recurrence rates are very less
Doctor :   ki-67 is a marker for the aggressiveness of the tumor
Doctor :   our main concern is metastasis
Doctor :   esp to the bone
User :   yes, i was worry about that but now that the tumor is gone, the chemo herceptin combo would hopefuly help avoid recurrence
Doctor :   if the results are negative now it does not really matter as you are right it was caught early
User :   I had the surgery 3 days ago
Doctor :   the only issue with aggressive tumor is that it can spread fast that's all and once its out ki 67 has little importance
User :   I thought a bilateral would be safer on this case considering the nature of it and the node negative
Doctor :   i will honestly tell you that the recurrence rate also is less if you are a true positive person
User :   positive attitude you mean,,right
Doctor :   remember to be strong and a strong desire to live and fight can make the body in a fight mode to block any recurrence
Doctor :   that is also crucial
Doctor :   yes it safer to have a bilateral and with nodes negative the chances are extremely low
User :   I guess the p53 mutation would mean the same as the k-67 when it comes to fast growing but not relevant once out
Doctor :   yes it the basic mutation that caused it
Doctor :   p 53 is a gene that protects the cells from forming tumor cells .
Doctor :   dont worry now
User :   Well doctor, thank you for your time. You made me feel better
Doctor :   take care of your self you have a wonderful life ahead of you
Doctor :   make the most and enjoy be positive and happy
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