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HIV related information, cd3 and cd4 values - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: HIV and AIDS
Answered by

General & Family Physician
Practicing since : 2004
Answered : 40 Questions
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User :   yes..i like to ask about cd 4 and cd 8 cells and if lower cd 4 and ratio cd4/cd8 can be other things than hiv..and how often that is
Doctor :   CD 4 and CD8 cells are mainly used in evaluation of DIV infections,
User :   hello
Doctor :   Though other class of HTLV virus can also have minor effects on these cells they do not cause much effects on these cells.
User :   Yes..but if you have lower cd 4 27% and ratio cd4/8...0,9...what other things can get it lower more than hiv?
Doctor :   And hence presently the CD4 counts and CD4/cd8 ratio are only in the HIV evaluation.
User :   But what about other viruses?
Doctor :   The other virus except for the other classes of retro virus ( which are uncommon though to cause infections in human ) do not affect CD4 and CD8 cells.
User :   Do the cmv effect it??
Doctor :   No, CMV does not cause much effects on these cells.
User :   ebv?
Doctor :   Apart from the retrovirus, these cells are not affected to the severe extents.
User :   Then....what about the values i have given above....its on the limit....what can it be...?
Doctor :   Though reduction in the white blood counts does happen with almost all the viral infections, the CD4 cells and the CD8 cells are not affected to severe extent.
User :   What about the numbers above..your comment?
Doctor :   One cannot predict the causative virus based on the CD4 or CD8 cell counts.
Doctor :   A brief clinical examination and other serological tests such as the ELISA or DNA PCR technology is needed to diagnose the viral infections.
User :   So if I have cd 4..27% and cd4/8 ratio 0,9 its not possible to say anything about that?
Doctor :   This applies to HIV too.
Doctor :   May I know the reason why these test were done?
User :   What is your ideas about the levels? What can it be?
Doctor :   The values are in the normal limits.
User :   So it is not values that you would say should make me concerned and worried??
Doctor :   A CD4 count of less than 15% indicated immunocompromised status.
Doctor :   Yes, your values are within the limits.
Doctor :   May I know if you were tested for HIV?
User :   I did take a lot of bloodtests via a big healtcheck up..and this together with a high cytomegalavirus igg at 150 came up...and then I have felt ill..maybe from the igg cyto...and the low cd 4..or what do you think....or shall I see the values as totally normal....and what about igg cyto 150...?
Doctor :   Your values are CD4 and CD8 cells are within the normal limits.
Doctor :   IgG immunnoglobins values do not indicate recent infections.
User :   But when I look at the internet sites...I found that levels under 35 is too low and levels under 1,1 are too that wrong then....
Doctor :   Infact IgM immunoglobin is the indicator of recent infection.
User :   See my other question
User :   The it false that is not good enough or is it within the normal limits as you say
Doctor :   Let me explain to you.
Doctor :   The CD4% refers to the percentage of CD4 present in the lymphocytes.
Doctor :   A CD4% any where between 20 to 40% is considered normal.
Doctor :   A normal CD4% indicates that your immune status is normal at the time of testing.
User :   But why is there at the test a range from 35-60..and from 1,1 to 2,7-....?
User :   its mentioned cd3+cd4+ value and cd4/8 ratio
Doctor :   You mean to say that the test range for CD4% is mentioned as 35 to 60%?
User : says exactly...cd3+cd4+ ...35-60......and ratio cd4/8...1,1-2,7....??????????
Doctor :   Ok
User :   What do you mean with ok?`?
Doctor :   You had initially mentioned that only CD4% was 27
User :   What is the difference???
Doctor :   CD3+ and CD4+ are two different type of cells.
Doctor :   You probably are having slightly low CD3+ cells.
Doctor :   your CD4 and CD8 cells are within normal limits.
User :   yes...but there is a value for only cd3 that is 67...I do not understand...the cd3 cells are normal....inbetween???!!!!
Doctor :   Is it possible to send us the scanned reports of the test to us?
Doctor :   If possible can you send us those to
User :   I can write it down....cd3...67.....; cd3+cd4+...27...., cd3+cd8+...40...cd4/8 ratio 0,9..there it is..
Doctor :   May I know what is the test range mentioned against CD3+cells?
Doctor :   Are you there?
User :   yes I am......
User :   57 to 77 i think
Doctor :   I would suggest you to get an absolute CD4 counts done to verify these values.
User :   But is not a cd4 percentage more secure abouty the numbers?
Doctor :   The ratio is not an absolute indication of CD4 counts.
Doctor :   Let me put it across to you in simple terms.
User :   OK....thankyou..
Doctor :   CD3, CD4 and CD8 cells are class of lymphocytes.
Doctor :   with CD3 and CD4 belonging to one class while CD8 belongs to another class.
Doctor :   All these cells are essential for the functions of immunity.
Doctor :   Of these three, those of importance are CD4 and CD8cells.
Doctor :   All these cells are affected in conditions of immunosuppression caused by infections.
Doctor :   Based on your reports, there are two possibilities.
Doctor :   1. There is a possible chances that either CD4 or CD3 cells being low.
Doctor :   Since CD4 cells are more important in the functions of the immunity and as the CD3 cells values have been mentioned, I had suggested you to get the individual CD4 cell count.
User :   I understand....but what about the ti normal within my numbers than nirmal?....27 and ratio 0, the cd 8 cells were normal...than you probably can see the the values normal...
Doctor :   If the 27% is both Cd3 and CD4, then they are under lower limits.
Doctor :   The ratio of CD4 and CD8 cells are within normal limits.
User :   But the text is...1. cd3+...;67........2. cd3+cd4+: 27
Doctor :   Since the CD3 cells are in normal limits and CD3 and cD 4 cells are low, I suggested you to get the total CD4 counts.
Doctor :   Have you followed?
Doctor :   The ratio of CD4 and CD8 can be normal even if both the values are low?
User :   But what does it mean with cd3?...67....and then it only the cd 4% percentage that is measured..percentage of what??
User :   And the cd3 value??
Doctor :   CD3 and CD4 = 27 means the total CD 3 and CD4 cells.
Doctor :   And the CD 3 count is the absolute value of CD3 cells.
Doctor :   Have you followed?
User :   Why do they use cd3 and cd4 together???
Doctor :   As I mentioned earlier, CD3 and CD4 belong to one class and the CD8 belong to another class.
User :   The cd3+cd8 test.. are also in the reference points...not low.
User :   The cd 3 for itselfs..and the cd3 and 4 together in percentage??Why
Doctor :   To help you better, can you send us the scanned copy of your reports to XXX.XXX
User :   I will...but can I get an anser directly??...and as far as I understand you seems to say that the numbers are normal...
Doctor :   I shall get back to you after going through those reports through a mail to you.
Doctor :   Have you followed?
User :   your name..
Doctor :   Please confirm your email id.
Doctor :   My name is Dr XXX
User :   XXX
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