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Endometrial cancer and breast cancer - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: Cancer
Answered by

General & Family Physician
Practicing since : 2005
Answered : 2408 Questions
User :   I have had 4 corticosteroid injections in the past 2 years for DDD, they are a godsend to help me to keep me mobile and out of pain. however I'm concerned, that I may be having side effects. I have had ammenorea for 6 months, although my fsh / lh shows I am not yet menopausal. A round of Medroxyprogesterone produced nothing. Also I have been determined to be going through a leukomoid response, cause unknown. I had no problems prior to last summer. Could this be be from the injections or could the other 2 conditions be related without having anything to do with it? I have been advised to find a good Internist
Doctor :   Hi
Doctor :   Dr
User :   Hello Dr
Doctor :   let me read ur query
Doctor :   having no periods for a long time, could be due to hormonal issues
Doctor :   taking steroids can alter the production of gonadotrophins in the hypoithalaamus of the brain
User :   Would this also cause the elevated white count?
Doctor :   usually steroids reduce the WBC counts
User :   So I am most likely looking at separate issues?
Doctor :   may i know your age ?
User :   40 years
Doctor :   and have you had your periods regularly before ?
User :   yes very regular
Doctor :   have you ever been on birth control or IUD s?
User :   years ago. I had a tubal ligation 7 years ago
Doctor :   ok
Doctor :   was any pelvic ultrasound done recently ?
User :   No
Doctor :   the cause of lack of periods could be due to 2 reasons
Doctor :   1, absence of the hypothalamic impulses for periods to occur
Doctor :   2. increased estrogen levels inhibiting the hypothalamus from send them instead (this action is similar to birth control pills) , but this estrogen being released by tissues elsewhere in the body including the adrenal gland or the cysts in the ovary
Doctor :   so blood work to check for the 2 causes and an ultrasound pelvis (for cysts within the ovary) would be helpful
User :   I do have a hx of ovarian cysts some which have ruptured, what is your opinion on how to proceed?
Doctor :   in that case, a pelvic ultrasound would be a starting point
User :   What are the recommended blood tests?
Doctor :   check for additional cysts and if present, getting them treated would be helpful
Doctor :   blood tests, include serum estrogen, estradiol levels
User :   If Left "unchecked" what could result?
Doctor :   you may not have periods, or you may have iregular periods
Doctor :   if the estrogen levels remain high, chances of cancer of the ovary can occur
Doctor :   or the cysts may enlarge, rupture or twist on themselves resulting in torsion requiring emergency surgery
Doctor :   the increased estrogen also predisposes to breast cancer and endometrial cancer too
Doctor :   i hope i have answered your queries
Doctor :   and you have understood my comments
Doctor :   Are you there ?
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