GHBP(Growth hormone binding protein)

It is a carrier protein for growth hormone (GH). It is coded by the gene which codes growth hormone receptor.Growth hormone-binding protein (GHBP) corresponds to the extracellular domain of the GH receptor and is closely related to measures of body composition and, specifically, to size of visceral fat tissue.Circulating growth hormone-binding protein (GHBP), in humans, is the proteolytic product of the growth hormone receptor (GHR).

GH-binding protein (GHBP) corresponds to the extracellular domain of the GH receptor (GHR) and has been shown to be closely related to body fat.Growth  hormone binding Protein (GHBP) is the soluble, extra-cellular domain of the growth hormone (GH) receptor and is an integral component of the growth hormone-insulin-like growth factor (IGF) axis. Depending on the species, it is either a cleavage product of the GH receptor or a splice variant of the GH receptor gene.The biological role of the GHBP is still unclear due partly to the previous lack of reliable and convenient assays and also due to the complexity of the in vitro effects

Functions of GHBP

GHBP modulates GH action via a variety of mechanisms.

• It inhibits GH action by competing with the GH receptor.The GHBP also prolongs the half-life of GH in the circulation by complexing GH and delaying its elimination.
• It can be measured by using Growthhormone binding protein ELISA test.

The main clinical use of GHBP measurements is in the diagnosis of genetic growth hormone insensitivity (Laron syndrome), where the levels are typically decreased.