Selective serotonin reuptake inhibitor

Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor ( SSRIs ) are a class of compounds typically used as antidepressants in the treatment of depression , anxiety disorders , and some personality disorders . SSRIs are believed to increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell , increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor . They have varying degrees of selectivity for the other monoamine transporters , with pure SSRIs having only weak affinity for the noradrenaline and dopamine transporter . The efficacy of SSRIs in mild or moderate cases has been disputed. A 2010 meta-analysis states that The magnitude of benefit of antidepressant medication compared with placebo ... may be minimal or nonexistent, on average, in patients with mild or moderate symptoms. For patients with very severe depression, the benefit of medications over placebo is substantial. This analysis discarded a great majority of FDA-approved antidepressant studies, including those that used placebo washout periods typically used as controls. SSRIs are the first class of psychotropic drugs discovered using the process called rational drug design , a process that starts with a specific biological target and then creates a molecule designed to affect it. They are the most widely prescribed antidepressants in many countries.

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