Metformin ( BP , pronounced , ; originally sold as Glucophage ) is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes , in particular, in overweight and obese people and those with normal kidney function. Its use in gestational diabetes has been limited by safety concerns. It is also used in the treatment of polycystic ovary syndrome , and has been investigated for other diseases where insulin resistance may be an important factor. Metformin works by suppressing glucose production by the liver. Metformin is the only antidiabetic drug that has been conclusively shown to prevent the cardiovascular complications of diabetes. It helps reduce LDL cholesterol and triglyceride levels, and is not associated with weight gain. , metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines (the other being glibenclamide ). When prescribed appropriately, metformin causes few adverse effects (the most common is gastrointestinal upset) and is associated with a low risk of hypoglycemia . Lactic acidosis (a buildup of lactate in the blood) can be a serious concern in overdose and when it is prescribed to people with contraindications , but otherwise, there is no significant risk. First synthesized and found to reduce blood sugar in the 1920s, metformin was forgotten for the next two decades as research shifted to insulin and other antidiabetic drugs. Interest in metformin was rekindled in the late 1940s after several reports that it could reduce blood sugar levels in people, and in 1957, French physician Jean Sterne published the first clinical trial of metformin as a treatment for diabetes. It was introduced to the United Kingdom in 1958, Canada in 1972, and the United States in 1995. Metformin is now believed to be the most widely prescribed antidiabetic drug in the world; in the United States alone, more than 48 million prescriptions were filled in 2010 for its generic formulations .
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Premium Questions (95)
Dear Dr: I am a patient of DM type II, essential hypertension, hyper uricemia (for the past 2 months)
I am aged 62 Male pt body wt 121 Kgs brought down to 112 Kgs with the help of dieting. Had quit smoking 22 years ago, height 6 . quit regular...
OILY,ORANGE DISCHARGE FROM RECTUM FLOATING IN TOILET WITH OR WITHOUT A BM.I AM DIABETIC AND HAD PANCREATITIS 13 YEARS AGO.
Hi,
My doctor suggested me to use Betacap TR 80mg. If I take it in night, I get diziness and severe headache sometimes. I'm 34 and my heart rate is 110 Bpm. I'm little low on Vitamin B12 (vegetarian) and started taking Methylcobalmin 50mg at...
I am 37 years old with type 2 diabetes. My height is 6ft 2in and weight is 185 lbs. Blood pressure and cholesterol tests are normal.
I was diagnosed with diabetes 12 years ago. For the first 11 years, I took Glucotrol, Glyburide and...
I am 23 yrs old and have pcos since 1 yr. At the start of the disease doctor prescribed me ginette 35 and metformin. I took that and had periods for about two months with medication. But later I discontinued. Since...
I am taking Ecosprin 75, I am type 2 diabetic, my sugar level are 89-174.
can I stop taking this drug, I am regularly taking Glyciphase 250, Glimestar1mg, before food morning and dinner. in addition I am using Ramiprill 10mg after breakfast along...
constant lower back ache, nauseous and hungry at the same time, sensation of getting a period, no spotting, feel tired (eyes strained), stomach bloated
Female, 28 years old, 50kgs 5"3
Irregular periods with mild pcos
last period was 1st week of...
Question: Is it required to stop meformine in pregnancy for women with PCOS history? Any other suggestion ?
Detailed Background below ( see attached document for reports and treatement history )
My wife (AGE 26+,...
My husband is type II diabetic. His physician says his blood sugars are between AIC #'s 6-7 (some tests were fasting -others random). His home testing fasting blood sugars have recently been 128, 123, and 133. He takes metformin which does not...
Partner - male, 71, hypertensive, overweight, bottle of red per day has fasting glucose of 283 today (yesterday 281, day before 240). Refuses to consult medical profession. Any tips?
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Online Doctor Chat (74) - Metformin
User : hello
Doctor : hi
Doctor : how can i help you
User : ive been having pains in my lower left stomach
User : going into my back
User : i went to the hospital 2 days ago,they did a cat scan and urin test
User : said nothing was found,i...
Doctor : Hi
Doctor : Dr XXX here
Doctor : How may i help you?
User : Hello Doctor.
User : This is XXXXXXXX from XXX , XXX
User : My father was prescribed from XXX...the following medicines
User : Ghizid
User : Rilaa
User :...
User : hi
Doctor : Hi.
Doctor : How can I help you?
Doctor : Hi.
User : i suffer from pcos
Doctor : Please go ahead with your query.
User : i was taking medicine metformin was this
User : i had to get period on 28th but did not get
User :...
Doctor : hi
User : hello doctor
Doctor : how can i hel you
User : i am a diabetic patient
Doctor : ok
User : but havent chckd my sugar level for some time now
User : i lead a normal life
Doctor : ok
Doctor : wen did you check it last...
Doctor : HI
Doctor : HOW CAN I HELP YOU
User : Hi..
User : I'm a 30 yr old diabetic..
Doctor : OK
User : have been taking glimperide 2mg daily
User : in the morning
Doctor : OK
User : along with a metformin 500 and aztor asp in the...
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Public Forum (493) - Metformin
2 Answers
I usually take diamicron 30mg just before breakfast and after breakfast I take metformin 850mg. Today I forgot to take diamicron before breakfast, so after breakfast I took both diamicron and metformin together. Will it cause any problem for me, I am little tensed. Appreciate a reply asap. Thank you
Hi I m 21 and these mont I have my period very light I have lots of nause I m never hungry 1 puke 2 times and I m always sleppy, sometimes I think in something of food that I really tink that I want but at the sametime my nauseas become more streinght... I m married and I m not using any protection... I m drinking Glucophage 3 pills a day,...
1 Answer
I am 60 years of age. Hypertension patient for more than 6 years. i am on beta cap TR 40 mg and Telma H 40mg. I am using the BP apparatus Relion at home. It invariably shows my BP as 139/94. My recent blood tet for sugar monitoring Fasing is 129 and PP as 290. I am advised for T. Metformin 500mg BD and T.Glimpride 1mg. I want your opinion on...
1 Answer
I have had regular periods since I have started taking Metformin I am currently 6 days late for my period I have cervicitis and I am wondering if that could be the cause for it being late or if I should take a pregnancy test
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hello, i have a question.. i have been trying to conceive for a year now, i was recently prescribed metformin , and i think i am pregnant .. for the past 2 weeks now i have had a low grade fever every day, i have had stomach cramps , i took 4 pregnancy tests , 2 which looked like a faint positive then 2 negative, i have been having what i think...
1 Answer
Hi Doctor , I have Pcod but i dont find time to do exercise.Now I am climbing stairs instead of using lifts and instead of using two wheelers going for walk of 15 mins.I am trying to conceive(married since 4 months ago).under the mediciation of Metformin(gylcomet).Please suggest ur views
hi, good day to you. i am 28 years old,married & trying to conceive. Last month November 19th i found out that i have polycystic ovaries,so my OB advised me to take metformin , & clomiphene citrate 50mg on my 2nd cycle for 5 consecutive days & try to conceive as soon as my menstruation stops. my OB told me to do pregTest on Dec.19 if my period...
2 Answers
Dear doctor I m 29, F, I have PCO and irregular period I wanna be pregnant DR said your LH & progesterone also is low , she gave me spironolactone , Glucophage( metformin ) & anti pregnancy tablet for regularity & PCO for two months she said after that we will proceed for pregnancy. I never try for pregnancy , should I do upper procedures? What...
I have PCOS . My periods are very few n far between when im not taking my Metformin . Saturday there was very SLIGHT indicator that my period was coming. So i put a tampon in. In the morning it was clean (the tampon). Then Sunday night after my Husband an I had sex there was a lot of blood so i figured it was my period. but im the morning there...
Hi I have been dignosed as pcod 1.5 years back. I was unmarried that time. I have been on krimson 35 for an year approx , but due to some understanding gap i did not took metformin now after marriage after two months i stopped taking krimson. my inlaws wanted me to go through homeopathic medicience. i did not had periods for three months . so i...
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