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Lamotrigine

What is Lamotrigine?

Lamotrigine , marketed in most of the world as Lamictal by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I.

Chemically unrelated to other anticonvulsants (due to lamotrigine being a phenyltriazine), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver.

Lamotrigine was developed in 1994.

Questions and answers on "Lamotrigine"

Hello, Im taking Buproprion 300mg/day and Lamotrigine 200mg/day for Bipolar2. I find I go through many moods throughout the day and usually start the day quite depressed and get better as the day goes on. Im wondering if increasing the dosage of lamotrigine may help?
Thank you, Zoe
Hello Zoe,
I understand your mood alterations and the ensuing toll it takes on you. But increasing the dose of lamotrigine more than 200mg/day may not help.
Despite this, a trial of increased dose can be given. Better to divide the dose into two doses daily when increasing dose. I recommend you...
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yes I have a depression& I was on sertraline then I start losing my balance, then she put me on lamotrigine is that a good thing Mabel What would you recomend
Brief Answer:
It can be used for augmentation.

Detailed Answer:
Hi Mabel,

I read your query and do understand your concern regarding starting lamotrigine.

Lamotrigine is often used as an augmentation agent in case a person is not responding to the 1st drug. However, it is not used as a first...
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I have been treated for major depression since my dad died. I was taking 40 mg of Paxil, 1mg Clonazepam and 50 mg of trazadone. I took all this medication at night. The medications seemed to quit working. I tried Prozak for depression but it didn't work with my anxiety. Now my doctor has me taking Amytriptilene and Lamotrigine in addition to the Clonazepam and Trazadone. I still have anxiety that keeps me from working
Brief Answer:
Try venlafaxine rather than lamotrigine

Detailed Answer:
Hi
Thanks for using healthcare magic. I, Dr Abhishek Kapoor, would help you in this query.

In your case, i would suggest venlafaxine rather than lamotrigine. Lamotrigine is a mood stabilizer and help to control mood swings. If...
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Yes, please... I am taking Levetiracetam 1500mg 2xs a day and Lamotrigine 25mg 2xs a day. I am having problems concentrating, even focusing my attention. I am having blurry vision and cannot sleep at night. Is this because of the combination of these drugs together?
Hello

Thanks for the query

Combination of Levetiracetam and Lamotrigine should not cause sleeplessness. I advice you to approach your physician for a neurological check up to rule out other causes of sleeplessness like sleep apnea, thyroid disturbance, depression etc

I hope I was of help...
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My girl friend is going through custody battle she has been accused of abuse of opiates. She has a doctors prescription for:
Zopidem 0.125 Mg
Lamotrigine 25Mg
Citalopram 20Mg
Are any of these considered an Opiate?
If so how long does she need to be off them to have a clean UA?
Brief Answer:
None of those medication are considered opiates.

Detailed Answer:
Hello and welcome to Healthcare Magic. Thanks for your query.

None of the medication that your girlfriend is on are considered as opiates.

- Zolpidem is a non-benzodiazepine sedative medication.
- Lamotrigine is a...
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I am on several meds and have been for a year now. I feel my mental health is declining and my doctor only wants to prescribe more meds. I'm depressed, have frequent panic attacks and have thought about harming others. I can't get into see another psychiatrist until the end of the month and if I go to the er they will admit me to the psych ward for 3 days then I'll be released. Could this problem be because of my meds? I am currently on ziprasidone 120mg, buspirone 15mg, zolpidem, 5mg xanex .25 (replaces ativan). I take all of these meds 1 x daily. I've been diagnosed with bipolar but don't believe this is acurate I forgot one...I also take lamotrigine 150 mg...that's it
Brief Answer:
The medications not right for bipolar

Detailed Answer:
Hello,
Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through.

If you have mentioned your diagnosis as bipolar, the according to...
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HI! I HAVE BEEN DIAGNOSED WITH BORDERLINE PERSONALITY DISORDER AND BI-POLAR DISORDER AND AM REVIEWING THE MEDS I AM TAKING FOR IT WHICH ARE TOPAMAX 75MG/DAY, CIPROLEX 20MG/DAY & LAMOTRIGINE 50MG/DAY. 2 OF THOSE, I LOOKED UP ARE TO TREAT EPILEPSY OR MIGRAINES??
hi. so you have been diagnosed as borderline personality, that must be because of your mood fluctuation, problems in interpersonal relationships and impulsive and reckless behavior. the meds u r receiving are antiepileptic like topamax and lamotrigine, but they also work as a mood stabilizer when...
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HI! I HAVE BEEN DIAGNOSED WITH BORDERLINE PERSONALITY DISORDER AND BI-POLAR DISORDER AND AM REVIEWING THE MEDS I AM TAKING FOR IT WHICH ARE TOPAMAX 75MG/DAY, CIPROLEX 20MG/DAY & LAMOTRIGINE 50MG/DAY. 2 OF THOSE, I LOOKED UP ARE TO TREAT EPILEPSY OR MIGRAINES??
Hello,
Thanks for using healthcaremagic.

Borderline Personality disorder has frequent episodes of depression and anger outburst. Simultaneously you have bipolar disorder.
So you need to be treated with anti depressant, mood stabilizer, and medicines to control anger.
Cipralex(Escitalopram) is an...
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HI! I HAVE BEEN DIAGNOSED WITH BORDERLINE PERSONALITY DISORDER AND BI-POLAR DISORDER AND AM REVIEWING THE MEDS I AM TAKING FOR IT WHICH ARE TOPAMAX 75MG/DAY, CIPROLEX 20MG/DAY & LAMOTRIGINE 50MG/DAY. 2 OF THOSE, I LOOKED UP ARE TO TREAT EPILEPSY OR MIGRAINES??
Hi,

Topamax and lamotrigine are indeed used to treat epilepsy and migraine, but both of these are second line mood stabilizers as well. Hence, they may be used in bipolar disorder as well. However, they are not the first line of treatment, unlike other mood stabilizers like valproate and lithium....
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