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Crohn's disease

What is Crohn's disease?

Crohn's disease, also known as Crohn syndrome and regional enteritis, is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus. Signs and symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, and weight loss. --> The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction also commonly occurs and those with the disease are at greater risk of bowel cancer.

Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. --> Diagnosis is based on a number of findings including biopsy and appearance of the bowel wall, medical imaging and description of the disease. Other conditions that can present similarly include irritable bowel syndrome and Behçet's disease.

There are no medications or surgical procedures that can cure Crohn's disease. Treatment options help with symptoms, maintain remission, and prevent relapse. In those newly diagnosed, a corticosteroid may be used for a brief period of time to quickly improve the disease with another medication such as either methotrexate or a thiopurine used to prevent recurrence. An important part of treatment is the stopping of smoking among those who do. One in five people with the disease are admitted to hospital each year, and half of those with the disease will require surgery for the disease at some point over a ten-year period. While surgery should be used as little as possible, it is necessary to address some abscesses, certain bowel obstructions, and cancers. Checking for bowel cancer via colonoscopy is recommended every few years, starting eight years after the disease has begun.

Crohn's disease affects about 3.2 per 1,000 people in Europe and North America. It has historically been more common in the developed world. Rates have, however, been increasing, particularly in the developing world since the 1970s. It tends to start in the teens and twenties, although it can occur at any age. Males and females are equally affected. The disease was named after gastroenterologist Burrill Bernard Crohn, who, in 1932, together with two other colleagues at Mount Sinai Hospital in New York, described a series of patients with inflammation of the terminal ileum of the small intestine, the area most commonly affected by the illness.

Questions and answers on "Crohn's disease"

I had a capsule endoscopy and balloon enteroscopy that found multiple apthous ulcers in my mid to terminal ileum. The gastroenterologist thought that this was consistent with Crohns disease. Biopsies taken in the terminal ileum and colon showed normal pathology. I am waiting to see the gastroenterologist at a followup visit. I continue to have a lot of right lower quadrant abdominal pain and iron deficiency anemia. Could this still be Crohns disease in the face of normal biopsies?
Yes, Crohn's disease is sometimes hard to catch on the biopsy unless you get right on the ulcer. It has normal tissue frequently in between. Your doctor could do blood tests to help confirm or try you on a 5 ASA med e.g. laid, to see if it helps . That is a good medicine for ill Crohn's....
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I have Crohns disease and have had a resection and now have b12 deficiency mainly due to Crohns in terminal ileum where b12 is absorbed. Prior to this I was diagnosed with bipolar II disorder, I have been on many pills and recently been put on depokate. I've had problems which i can attribute to b12 deficiency for years, so my question is could these problems and the bipolar diagnosis all be related to b12 as I've taken numerous meds and still had problems with mood swings, could the depakote have hindered the b12 problem, and would folic acid be wise to take with the b12 injections when I soon start receiving or is that just needed with an oral suppliment to help b12 absorption. Would folic acid interfere with depakote. From my message you can tell I'm very confused. Im starting to believe I don't have bipolar at all and this is all down to b12. I've been saying to the docs I've had problems with memory, numbness in hands feet arms and legs, extreme fatigue, which is hard to look after my daughter, trouble sleeping, confusion, headaches, which has always been attributed to stress but now I'm beginning to think it's been a simple mis diagnosis, I'm also worried that I'll have long term effects. I'm thinking of gaining access to my medical records too as I believe the docs think I'm some kind of hypochondriac and seeking attention. But I've lost my appendix due to it taking them 5yrs to find out it wasn't ibs and Crohns disease and I've had two breakdowns in this time also, not to mention side effects from the numerous bipolar drugs, not least the latest hair loss from the depokate.. Please could you give me some answers.
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Hi, I'm so sorry to hear about the troubles you are going through, as you mentioned your B12 is low due to Crohn's disease. I believe most of your symptoms could be due to B12 def. as numbness, memory problem and fatigue are the complications of B12 def., you need replacement of b12 by injection,...
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Hi,

I had a chirurgical last month because of my Crohn's disease. I wanted to know if i can try MDMA and if it will be worst because i take pentasa 500mg?

Thank you.
Brief Answer:
Not advisable

Detailed Answer:
Hi

Thanks for writing in

Under all prevailing conditions MDMA is not recommended

The stimulant effects of the drug, can lead to dehydration, hyperthermia (dangerous increase in body temperature), and heart or kidney failure.

Hope this helps
Do write...
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i am a 29yo male with P/Q antibodies, currently around .24. I also recently had a CT Scan done and it showed small pockets, possibly Crohns. I had a colonoscopy and it said small ulcers in the ileum and also adematous in the colon. is this all related or separate issues. also my white blood cell count is rising...
Brief Answer:
inflammatory bowel disease

Detailed Answer:
Crohn's disease is an inflammatory bowel disease (IBD). It causes inflammation of the lining of your digestive tract, which can lead to abdominal pain, severe diarrhea and even malnutrition. Inflammation caused by Crohn's disease can...
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I have crohn's disease and sometimes have severe pica and eat chalk. I ate chalk last week (but it is not abnormal for me to have a stick or two a day) and now have severe diarrhea. At the same time I started taking vitamin D supps and iron because my blood tests came back showing severe anemia and a mild vitamin D deficiency.
Brief Answer:
Need more information

Detailed Answer:
Hi,
Thanks for posting your query.
I am Dr.R.K and I am pleased to assist you.

Pica may be a manifestation of the iron deficiency you have and you are doing the right thing by taking iron supplements.

How long have you been affected by Crohn's...
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i have dried up ovary pain, huge abdomain, been diagnosed with chrons disease/diabetic. i weigh 238 down from 285. i am miserable. they also say i have proctitis? so i no longer have diareahia. just the bloating every -little bit of celiac food i eat. i thank you for your help.
Hi Dear !! Thanks for your query to HCM.
Read and reviewed query.
Based on facts of your query, You seem to suffer from-
Crohn's with Proctitis.This is autoimmune Whole GI Inflammatory disease.
Recheck with second GI surgeon by Biopsy reports to prove that its Crohn's pathologically.
Treatment-...
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My daughter had a biopsy yesterday of the vulva near the bottom. I think it's called the labia minoir. It is kind of in the shape of a horseshoe and grey in color. It is not a complete line though, it is broken up. She has Crohns disease. I am worried sick. What does this sound like?
Chrons is associated with colon so get your reports corrected.And its kind of inflammatoin so drugs are available to control the cause.
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