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topicLogo Creatinine

Creatinine (from the Greek κρέας , flesh, pronounced, krē- a-tə-nēn, -ən cre·at·i·nine ) is a break-down product of creatine phosphate in muscle , and is usually produced at a fairly constant rate by the body (depending on muscle mass). Creatinine starts to decompose above 295 °C. In chemical terms, creatinine is a spontaneously formed cyclic derivative of creatine. Creatinine is chiefly filtered out of the blood by the kidneys (glomerular filtration and proximal tubular secretion). There is little-to-no tubular reabsorption of creatinine. If the filtering of the kidney is deficient, creatinine blood levels rise. Therefore, creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR). The GFR is clinically important because it is a measurement of renal function . However, in cases of severe renal dysfunction, the creatinine clearance rate will be overestimated because active secretion of creatinine from the proximal tubule will account for a larger fraction of the total creatinine cleared. Ketoacids , cimetidine and trimethoprim reduce creatinine tubular secretion and therefore increase the accuracy of the GFR estimate, particularly in severe renal dysfunction. (In the absence of secretion, creatinine behaves like inulin .) A more complete estimation of renal function can be made when interpreting the blood (plasma) concentration of creatinine along with that of urea . BUN-to-creatinine ratio (the ratio of blood urea nitrogen to creatinine) can indicate other problems besides those intrinsic to the kidney; for example, a urea level raised out of proportion to the creatinine may indicate a pre-renal problem such as volume depletion. Men generally tend to have higher levels of creatinine because they have more skeletal muscle mass than women. Vegetarians have been shown to have lower creatinine levels. There exists several tautomers of creatinine. Ordered by contribution, they are: 2-Amino-1-methyl-1 H -imidazol-4-ol or 2-Amino-1-methylimidazol-4-ol 2-Amino-1-methyl-4,5-dihydro-1 H -imidazol-4-one 2-Imino-1-methyl-2,3-dihydro-1 H -imidazol-4-ol or 2-Imino-1-methyl-3 H -imidazol-4-ol 2-Imino-1-methylimidazolidin-4-one 2-Imino-1-methyl-2,5-dihydro-1 H -imidazol-4-ol or 2-Imino-1-methyl-5 H -imidazol-4-ol
109 Premium Questions
78 Online Doctor Chat
343 Public Forum Questions

Premium Questions (109)

I have been having mild stomach ache last one month, which is generally on and off the day. I was asked to take few test namely ESR, CRP(B&I), CREATININE , UREA, HAEMOGLOBIN.. The results are as follows : ESR : 59mm/hr / CRP: 2.58mg/dl /...
My dad had an angioblast 10 days back. His Creatinine levela re 1.88. He is a diabetic patient. What diet is suggested for this? He has to take care of his hear and creatinine levels.
Hi my daughter is 18 and her creatinine level was found 2.21 two days ago and 2.78 yesterday.I am really worried cause i have no idea what is happening. All the other test are good. She has not been sick or on any medication lately.
Hi, Doc my grandmother, age 83, an ashthama patient, has suffered from Hip joint injury but the operation has been withheld as her creatinine level is 3. i will be highly thankful if you give me all possible advices along with the medicine which...
25 years old, 182 cm, 80 kgs. 1 month earlier 14th dec 2011 i had hepatic liver abscess in the right lobe approximately 300 cc. they initally treated me with iv abtibiotics till 25th dec when it got melted. they drained the abscess on 28th and...
what is the actual work of the tab RENALOG ?is it advisable for patients with creatinine level -4.6?
Hi I am diabetic & hypertensive.recently my serum creatinine has come 1.20 & I am having some pain in lower back( left side). My albumin/creatinine ratio( urine) was just 2.3. My Doctor said no need of worry on kidney side. I am having spam pain...
Blood work results. I know that these numbers are in the high range. Why should I be concerned? What are these indicative of? A1C total 6.2%, leukocytes 13.9, creatinine 1.29. Should they be looked at in combination? All other test results are in...
High level of Urea & Creatinine ================== My mother has some heart failure and she began to take Revatio but then from February she got very high rate of Urea & Creatinine. She has the whole past year a level of 1.2 mg/dl of Creatinine...
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Online Doctor Chat (78) - Creatinine

Doctor : hi Doctor : how can i help User : hi User : hi Doctor : yes User : My Dad has a Creatinine level of 1.6 by his latest report Doctor : ok User : is it smothng to worry about User : his BP is 110/70 & his sugars is 165 PPBS Doctor...
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User : My 85-year-old mother is a nursing home resident having just been released from the hospital a couple of days ago. She has been very weak and lethargic today. She had blood work done this morning. It showed a BUN reading of 23 and...
Doctor : Hello User : hi.... User : i am having high creatinine User : what is the remediy? Doctor : Please provide these details: Age, Gender, Location, Occupation, Marital status, Height and Weight. User : you there? User : 25, Male,...
Doctor : hi Doctor : how can i help you User : hello doctor, i am xxxxx Doctor : ok User : i am having serum creatinine 3.9 Doctor : ok Doctor : since when User : is it dangerous for my kidneys Doctor : when was the test done Doctor :...
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Doctor : hi Doctor : how can i help you? User : hi User : for care Doctor : ok User : i am right nephroctomy man age 35 Doctor : ok User : past one year oprated due to p.u.junction failure Doctor : ok Doctor : on the right side? User :...
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Public Forum (343) - Creatinine

1 Answer
HELLO SIR, YESTERDAY MY BROTHER HAS GONE FROM CBC AND CT SCAN TEST FOR HAVING LOWER RIGHT AND MIDDLE ABDOMEN PAIN. HIS WBC AND RBC SEEMS NORMAL. AND URINE IS SHOWING PROTIEN DEPOSITS. ALSO S . CREATININE IS 1.0 AND URINE IS ACIDIC .EPITHENIAL CELLS ARE 2-3 .PUS CELLS 1-2. RBC MORPHOLOGY IS NORMOCOMIC AND NORMOCYTES. WBC MORPHOLOGY IS -- NAD. HIS...
1 Answer
In the liver function test of my father, the following results Serum creatinine . 1.96 normal range Marked as .7 - 1.4 mg/dL Gamma G.T. 72 normal range marked as 0-45 IU/L SGOT 112 at 37 degrees centigrade normal marked as upto 46 U/L at 37 degrees SGPT 136 at 37 degrees centigrade normal marked as upto 49 U/L at 37 degrees centigrade Please assist
I am a KCD patient since 2005. My present creatinine level is 5.5. I would like transplant . Greatfull if your let me know the cost of transplant at cms please.
1 Answer
Sir, I am a kidney transplant patient and undergone transplant in the year 2002. Now my s. creatinine level is 1.8. I have been prescribed medicines Pangraf ..2 mg BD, Wysolone 5 Mg -- OD and Cell Cept 500 mg -- BD (Immunosupresive). My normal problem is of diahrrea which is treated by taking Norflox 400 mg x 5 Days.. BD by my doctor. But now it...
1 Answer
my husband has been a kidney transplant patient two years ago , recently he is suffering from severe diarrhea which improved after lacteol forte but new red rashes appear on his back and stomach, he is equivocal for CMV IGm and currently elevated serum creatinine level 1.92 , any advice since am not able to reach his doctor now
1 Answer
I am 57 years old. My S. Creatinine is 2.63.I have pressure & diabetics. CMC Hospital doctors think that is for longtime pressure. I took medicine of pressure. Is there any medicine for S. Creatinine. Regards Dr. Saleh (Not Physician )
3 Answers
Hello! My brother (44 years old) has 15.6 mmol/L Urea level and 276 u mol/L of creatinine in blood . is it very risky or is there any home remedy for that?? Thanks and regards
2 Answers
I am kindney patient and having a HB 11.40, Cholesterol 118, Calcium , Serum 9.50,phosphorus, serum 3.50, Urea 72, creatinine 3.49. Please advice me the diet and if possible the medicine may please be intiated to me. I am under treatment of Dr. Mahaptra, Nephrolgist, Dr R.M.L. Hospital, New Delhi. Please send me the reply on my email...
1 Answer
my mother is 46 n her blood urea is 177 n creatinine is 13i need to what are the reason behind increasing blood urea in body my mother is 46 n a month ago she went for surgery for heart n gt pace maker implanted her sugar level is 138 (morning ) n her blood urea is 177 n her creatinine is 1.35 also her sodium is 134 n her potassium is 2.46....i...
1 Answer
My mother(63) was detected for high blood sugar 8 years ago. She immediately took to strict dietary controls and maintained it in the range 140 (post parendial). She also started taking medication for the same since last three years. Six months ago, she started having problem of pain in shoulder joint(left initially then both). Physiotherapy was...
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