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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Having Phelbotomies. Bone Marrow Biopsy Done. Megakaryocytes In Bone Marrow Aspirate. Is It Normal?

I had a bone marrow biopsy done and I would like to know some information regarding the Aspirate Smear, here is what it said. Quality: Adequate, Cellularity: Cellular, Myeloid lineage: Synchronous and progressive, Erythroid lineage: Synchronous and progressive, Megakaryocytes: Occasional. Normal morphology. Is it normal to have Megakaryocytes in a bone marrow aspirate? Here was the differential: Blasts 0%, Promyelocytes 2%, Myelocyte/Meta 38%, Neutrophil 15%, Eosinophils 2%, Erythroid 27%, Lymphocytes 14%, Plasma cells 2%. M:E ratio 3:1, what does that mean and is it normal? Is it normal to have Promyelocytes and are all the percentages within normal ranges? Core Biopsy: Quality: Suboptimal (short core biopsy). Bone/soft tissue: Normal, Cellularity: Unable to determine but specimen is approximately 40%. Myeloid lineage: Progressive. Erythroid lineage: Progressive. Megakaryocytes: Occasional megakaryocytes with normal morphology. Others: No increase blasts or lymphoid aggregates. What does approximately 40% mean on Cellularity? Also had Special Stains: Aspirate smear Iron stain: No Histiocytic and sideroblastic iron (0/4). Core biopsy, Iron: No stainable iron. I was having Phelbotomies prior to this bone marrow test because I was given too much iron supplement, and my iron became depleted so it seems. My ferritin level at the time of the bone marrow biopsy was only 7. So is it normal to have Megakaryocytes in bone marrow aspirate, I megakaryocytes should only be in the bone marrow, not the aspirate, can you clarify this for me. And are Promyelocytes normal in the aspirate? Is the ratio normal 3:1? And is Cellularity 40%, is that normal? Would greatly appreciate your expertise opinion, thank you.
Fri, 14 Jun 2013
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General & Family Physician 's  Response
Megakaryocytes are the precursors of platelets,it occurs as 1:10,000 of the cells in the bone marrow.Depending on the age,about 40% myeloid cellularity would be normal .Promyelocytes are precursors of myelocytes or granular white cells.The aspirate drawn forms a part of the bone marrow,the presence of Megakaryocytes would therefore be normal.A M?E ratio of 3: 1 is normal.
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Having Phelbotomies. Bone Marrow Biopsy Done. Megakaryocytes In Bone Marrow Aspirate. Is It Normal?

Megakaryocytes are the precursors of platelets,it occurs as 1:10,000 of the cells in the bone marrow.Depending on the age,about 40% myeloid cellularity would be normal .Promyelocytes are precursors of myelocytes or granular white cells.The aspirate drawn forms a part of the bone marrow,the presence of Megakaryocytes would therefore be normal.A M?E ratio of 3: 1 is normal.