Hello & Welcome to HCM, I had gone through the case and found that if your constipation problem is not cured by laxative and enema then you must go for proper investigation because there are many cause like- -Inadequate water intake and fiber in the diet and activity or exercise or immobility. - A disruption of regular diet or routine; traveling. -Eating large amounts of dairy products. -Stress - Resisting the urge to have a bowel movement, which is sometimes the result of pain from hemorrhoids -Overuse of laxatives (stool softeners) which, over time, weaken the bowel muscles - Hypothyroidism - Neurological conditions such as Parkinson s disease or multiple sclerosis -Antacid medicines containing calcium or aluminum -Medicines (especially strong pain medicines, such as narcotics, antidepressants, or iron pills) - Depression Eating disorders -Irritable bowel syndrome - Colon cancer So go for proper diagnosis then take the proper medicine for the cause of constipation. There are some investigations like - Blood tests if a hormonal imbalance is suspected. -Barium studies to look for obstruction of the colon. -Colonoscopy to look for obstruction of the colon. Hope my advise will helpful for you. Thanks, Dr.Soni Verma Homoeopathic Physician and nutritionist