Brief Answer: gastrointestinal/psychiatric/autoimmune. Detailed Answer: Hello madam! i went through your troubles. they need to be addressed one by one.lets start with 1- canker sores/aphthous ulcers AKA recurrent aphthous ulcers are have many etiologies. in your case, your history of smoking and alcohol with previous history of herpetic stomatitis., you need to care for the oral hygiene and all oral issues are because of it.your gut is in trouble (diarrhoea, cramping, vomiting, previous smoking alcoholism) altogether adds to the gastrointestinal dysfunctions. take care of it.use fiber, healthy bowel habits, proper routine, early to bed early to rise, some antispasmodics, some oral gargles, some good oral anesthetic gels some pain relieving dental creams, vitamin c, avoidance of Gut stimulants like spices, westernised diets, caffeine etc, and you will start feeling the difference. and also your usage of gluco corticoids have compromised your immune status of oral hygiene adding to the trouble for symptomatic treatment of aphthous ulcers stop smoking and alcohol drinking start vitamin B12 orally. taper your glucocorticoids slowly. usee topical hydrocortisone betamethsone gels for ulcers topical tetracyclines over the ulcer will help it heal fast and prevent infection and stomatitis. use benzadymine hydrochloride mouth wash. chlrhexidine gluconate and bioadhesive rinses willhelp i am sure above treatments will help. if resistant step up to immunomodulation by thalidomides etc will be necessary. 2-Gut issues (diarrhoea, vomiting , nausea etc) part of the reason for it are drugs like oxycodones/percocets ( narcotics lower the gut motility) add to the trouble. and also the adderal/amphetamines, these are respomnsible for your diarrhoea , mood swingsabdominal pains, headaches, sleeplessness,and appetite lossand anxiety. so you should ask a doctor to stop them for you, the other issue is the psychological perspective. you have a lot on your plate and i am sorry for your troubles. you have the right to have a good loving husband and co operative surroundings. but you can not pay the price of your own XXXXXXX for that. remember if your antidepressants increase from 7 to 14 and you take all the xanax, it wont fix your issue. issue lies to get out and see the other face of life. you need a psychotherapy sessions with a good psychologist who will help you fight and guide you to manage the troubles. plus Type A personalities ( people who take alot of stress) is also the reason for gut troubles and aphthous ulcers. get some groups sign up which involves domestic issues and transitonal phases of life and share your feelings. they will help you calm down. get a healthy excercise, regular meals and sleep etc to get back to normal. life is too long to be wasted on useless troubles. you have the right to remain happy,, get some sessions please for your own happiness sake.you are well educated woman with a perfect back ground. you can do it. cheers. 3-Immune status verification past history of staph and ecoli infections are not significant in your issues. as you have gastro intestinal symptoms(nausea, dyspepsia, cramping etc)., neuro psychiatric symptoms(psychosis) and oral ulcers, i am suspecting some auto immune condition like SLE , behce't etc. i would advise you to check for ANA, Anti Double stranded DNA antibodies, C3 C4 complements assays to rule out the autoimmune disorders. You want to feel normal? i promise you will feel normal. follow my leads, do as i told you to. and see the miracles of life. i have seen worse. you can do it. i will be here to get you out of the trouble and put you back on track. Only you matter and you should know it. If you have any follow up questions ask me, other wise kindly close the discussion and rate the answer, i hope i was of some help. Regards Dr Khan

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