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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Chronic Hepatitis C, Liver Cirrhosis. Can Sulfazine Treat Liver Cirrhosis?

hi! i've got chronic hep c and liver cirrhosis (stage 4)... in reference to an article in the London Sun Times in 2006, it was reported that sulfasalazine had proved effective in treating alcoholics with liver cirrhosis and that patients some patients even exhibited a reversal in stages...i've been to two gastroenterologist , and the first one wadded copy of said article, threw it away , calling it rubbage! the second just said that there was absolutly no empirical evidence to support my questions regarding sulfasalazine and reversal of stages in liver cirrhosis... my contention has always been, what have i got to loose by taking the drug for 6-12 months and then having another liver biopsy? Today, i once again looked up sulfazine on the internet and WiKipeddia refered to the british 2006 article claiming liver damage reversal occuring after sulfasalazine administered to chronic alcoholics suffering with liver cirrhosis!!! at the next site, there was another claim similar...with footnotes about studies done on rats...please comment thanks,
Mon, 17 Jun 2013
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General & Family Physician 's  Response
Hello,
Very sorry to know that you are suffering from stage 4 liver cirrhosis.
There are definitely some studies which says that sulfasalazine holds promise for reversing scar tissue of liver cirrhosis but studies are not complete as yet and it's safety and efficacy has yet to be prooved in human beings.
Stage 4 liver cirrhosis is in compensated or decompensated stage.
In compensated stage your liver cells keep working normally but it can soon land up in decompensated stage where functions are disturbed and person develops confusion,ascites,jaundice,itching,bleeding etc.
The best treatment for you is to go for liver transplant as early as possible,lest it is late.
Thanks
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Chronic Hepatitis C, Liver Cirrhosis. Can Sulfazine Treat Liver Cirrhosis?

Hello, Very sorry to know that you are suffering from stage 4 liver cirrhosis. There are definitely some studies which says that sulfasalazine holds promise for reversing scar tissue of liver cirrhosis but studies are not complete as yet and it s safety and efficacy has yet to be prooved in human beings. Stage 4 liver cirrhosis is in compensated or decompensated stage. In compensated stage your liver cells keep working normally but it can soon land up in decompensated stage where functions are disturbed and person develops confusion,ascites,jaundice,itching,bleeding etc. The best treatment for you is to go for liver transplant as early as possible,lest it is late. Thanks