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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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When Will My Blood Pressure Become Normal After Starting 'lisinopril'?

I have high bp, age 40, height 5'11" weight this morning 269Lbs. Just stopped taking Avapro 300 mg(yesterday was my last dose), and switched to Lisinopril 40mg and Norvasc 10mg today. Meds were taken about 45 minutes ago, I always take them at morning to mid morning. My resting BP is currently 143/94, with heart rate of 81. The past few weeks those stats have been BP-140/80 range, HR-mid to upper 70s. Should I expect higher readings in the next few days, until the Lisinopril starts to work? Or are there any other negative symptoms I should expect? Thank you for your time.
Tue, 17 May 2016
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Internal Medicine Specialist 's  Response
Brief Answer:
The lisinopril effect begins within a hour .After 48 hours you will have a steady state of your blood pressure values.

Detailed Answer:
Hello,
Thank you for using HCM.
The lisinopril effect begins within a hour and after aproximately 12.6 hours, half of the drug is eleminated from the blood. Steady state is attained after two daily doses (every 24 hours), which means after 48 hours after drug administration .
The amlodipine levels in blood rise gradually to peak 6 to 8h after administration. It is extensively metabolised in the liver and is slowly cleared from the blood for more than 40 hours.
So your blood pressure will not be higher than 143/90.
After 48 hours you will have a steady state of your blood pressure values.
The most common side effect of lisinopril is cough. And the most common side effect of amlodipine is swelling of the ankles or feet.
Both can cause : headache, dizziness, depressed mood, drowsiness, gastrointestinal symptoms such as nausea, upset stomach, vomiting or diarrhea, skin symptoms such as mild itching or a rash .

Hope this is helpful.
Let me know if you need more clarifications. Otherwise please close and rate the answer.
Kind Regards,
Dr. Juarda
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When Will My Blood Pressure Become Normal After Starting 'lisinopril'?

Brief Answer: The lisinopril effect begins within a hour .After 48 hours you will have a steady state of your blood pressure values. Detailed Answer: Hello, Thank you for using HCM. The lisinopril effect begins within a hour and after aproximately 12.6 hours, half of the drug is eleminated from the blood. Steady state is attained after two daily doses (every 24 hours), which means after 48 hours after drug administration . The amlodipine levels in blood rise gradually to peak 6 to 8h after administration. It is extensively metabolised in the liver and is slowly cleared from the blood for more than 40 hours. So your blood pressure will not be higher than 143/90. After 48 hours you will have a steady state of your blood pressure values. The most common side effect of lisinopril is cough. And the most common side effect of amlodipine is swelling of the ankles or feet. Both can cause : headache, dizziness, depressed mood, drowsiness, gastrointestinal symptoms such as nausea, upset stomach, vomiting or diarrhea, skin symptoms such as mild itching or a rash . Hope this is helpful. Let me know if you need more clarifications. Otherwise please close and rate the answer. Kind Regards, Dr. Juarda