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The first use of chemotherapy
was done in 1940 with nitrogen mustard and folic acid
antagonist drugs by then nitrogen mustard was used in a chemical warfare.The first drugs were tested in acute lymphoblastic leukaemia(ALL) and they were aminopterin
and amethopterin which is now known as methotrexate
and it was used in 1948.And slowly the therapy was introduced in other forms of cancers and new drugs were added.