Thanks for your question on Healthcare Magic. I can understand your concern. No, you should not reduce your medicines without consulting your doctor. In my opinion, you are mostly having drug induced gastritis which is causing this low appetite. You are taking many drugs and they will definitely cause gastritis. So better to take antacid like pantoprazole on empty stomach (before taking all these drugs). Also start appetite stimulant like syrup betonin or syrup activate thrice daily. Also get done liver function test to rule out drug related hepatitis because this can also cause low appetite. Don t worry, you will be alright. Don t stop medicine by your own. Hope I have solved your query. I will be happy to help you further. Wish you good health. Thanks.