welcome to HealthcareMagicIrregular periods
and hot flushes are signs of menopause
but 42 is a bit early but surely menopause can be possible.See if you repeatedly have this problem if yes then it is menopause and if it is once in a while the delay in periods can be due to hormonal
imbalance also.Continue Gynaset as advised and for constipation
drink enough water;eat green leafy vegetables and have fruits and food rich in fibers and it will help to resolve constipation.