Hi Nilesh.. It seems that your wife may be having telogen effluvium. In this condition,the hairs fall in telogen stage of hair cycle. There may be some cause like...tension, anxiety,thyroid diseases, endocrinal diseases, hormonal diseases, diseases like typhoid, malaria,viral diseases,surgery,trauma,drugs like anticancer drugs ..methotraxate ,internal diseases,anaemia,nutritional deficiencies..... etc might precipitate the disease. Excessive sun exposure may be resposible for the disease. Dandruff may be responsible..it should be ruled out. If it is there, ketoconazole shampoo may be done. You consult dermatologist. If there is family history if DM, it should be ruled out by blood test.Investigations may be done to rule out thyroid disease,anaemia and other internal diseases. If they are there,proper treatment may be taken. Nutritional diet may be taken. Tab Biotin 10 mg daily may be taken for long time. And also vitamin E cap 400 mg daily may be taken with iron, calcium, zinc..etc in proper dose. Mild steroid lotion like beclomethasone may be applied on the scalp daily at night. Mild herbal shampoo may be done twice a week. Oil like almond may be applied on hairs to improve hair shaft quality. Tell her to be confident for good result.. Have patience..as the good result takes time.advise her to be free of tesion and worries and to be positive. She may feel better after few months treatment. I hope you got my answer. Thanks. Dr. Ilyas Patel MD