My husband of 64 yrs old has gallbladder cancer in its end stage and has spread to the liver, he has being doing very well since surgery on March 16, 2010. The surgery was and open and close situation, there was nothing the doctors could do. Its only now that his liver enzymes are significantly elevated, he has refused chemo treatment. This pass week end he has been stomach sick and very fatigued . At the time he was given 6 months without chemo. Despite of how well he has been doing. What how fast can this thing downgrade???