Hello dear, Thank you for your contact to health care magic. I read and understand your concern. I am Dr Arun Tank answering your concern. High TPHA and high VDRL is suggestive of infection of the syphilis. Treponema pellidum is the causative agent of the syphilis. This organisms is unique in its characteristic that it can pierce intact skin. So apart from sexual contact it can even pierce the skin with exposure of the infected person. Infected blood transfusion can also cause infection of the syphilis. No, if you are infected with the syphilis you should not plan the pregnancy. This bacteria can cause infection to the newborn and may cause some congenital malformation. So better is to avoid the pregnancy until you are infected. You can take the benzathine penicillin treatment under your doctors guidance. This will cure the infection. Treatment response will be evident by the falling titre of VDRL and TPHA. Once you are clear with the infection you can start the pregnancy planning. I will be happy to answer your further concern on bit.ly/DrArun. Thank you, Dr Arun Tank Infectious diseases specialist, HCM