I am a 49 year old female who has been struggling with chronic, extreme fatigue, joint pain, chronic sinus infections, asthma and hives for about 18 months. My eosinophil levels are running about 1600-2000 unless I am on steroids. My IGE levels are also very high. I have had every allergy test imaginable but all are negative. I had sinus surgery a few months ago and felt better as long as I was on the steroids but as soon as I tapered off, all symptoms returned and I am feeling terrible again. Allergist ordered lots of blood tests including some checking for specific mutations but all are normal except the eosinophils and IGE's. He wants to do a bone marrow biopsy, which I have scheduled but am looking for any help on what this could be. Unless I am on steroids, I feel terrible and asthma is hard to control but once I am on them, I feel normail again and the asthma is completely under control