Thanks for being here! In the past 3 mos. I ve had 4 episodes of swollen painful tongue. I have always taken benedryl, generally 50mg. with success. what always remains after the swelling is gone is a very painful tongue: the top, under the tip and generally one side. It s quite uncomfortable to speak. Last evening around 11 pm, I felt that telltale tingling beginning on the back of lt. tongue. I took ben. 50 mg. p.o. & went to bed. The swelling continued as did burning on tongue. Benadryl repeated w/same dose. Still got bigger until I was unable to swallow sputum. Around 3 a.m., my tongue left no swallowing room when I closed my teeth. Then I took a librax & 2 ibuprophen...for smooth muscle & pain relief. At 4 ish, I had one 25 mg. Benadryl & finally slept. Up at 1120!! omg...I m a nurse...I never sleep like that! Tongue less swollen, lispy to speak & areas of tongue pretty sore. Same amt. of swelling at 1120 am so I took another 50mg. Benadryl. No other meds with exception of routine a.m. meds ie: Aspirin 325 mg. 1, Bystolic 10 mg. 1 & Cital. 40mg. Birthdate: 03/05/41, 5 5 , breast cancer survivor, 7 yrs., allergic to Compazine, talwin, Augmentin, Triple Abx. cream & Flagyl. I also take librax prn for diverticulosis/ibs and zantac plus zyrtec @ hs to aid with new symptom of heartburn. I just retired from 50yrs in Nursing & continued good health is a requirement. I didn t change anything in the way of foods or cleaning items. Generally pretty darned healthy. Anything special come to mind with these symptoms? Thank you so much. Ann