Hi, Welcome to HCM. Infection of the bone marrow with the surrounding bone is called osteomyelitis. This iinfection is most commonly caused by Staphylococcus aureus bacteria. Usually this infection is caused if any penetrating injury through skin which reaches the bone or from blood which is carrying bacteria to the bone. When one of the major bones are involved like bones of the thigh, leg or arm, there are chances of infection spreading to the blood called as septicemia. If there is a fracture of a major bone, there could be dislodgement of the blood clot of the fracture which could cause emboli and block pulmonary vessels causing pulmonary embolism. This affects the heart. I suggest you discuss with your treating doctor the various ways of treating osteomyelitis without surgery. Identification of the bacteria causing infection is very important. Surgery under antibiotic cover will prevent spread of infection to a large extent. I hope I have helped you with this answer. Thanks