Hello concerned wife and thanks for writing to HCM I read you query and understand that the concern is regarding losartan and pantoprazole tablet your husband is taking few more details would have helped more: his age and occupation? his current bp values before and after medication? any drug or medical history?smoking habits? Coming to the query, Yes,losartan tend to cause a few side effects like the ones you described ,but is often rare and minimal Pantoprazole is recommended alongside to prevent heartburn that often accompanies losartan if your husband were my patient, i would recommend switching to another drug of the same class called olmesartan which has fewer side effects and is effective in most of my patients I would recommend adding a diuretic drug like hydrocholrothiazide thiazide also,if the bp remains higher even after taking olmesartan Please understand drug efficacy do vary patient to patient. If he is resistant/non tolerant to olmesartan,then i would suggest him taking nifedipine which is also a commonly used antihypertensive drug and is very effective And importantly,aside from the drug intake ,my most important advise to him would be lifestyle modifications like -maintain ideal weight,stop smoking,do regular exercise and have a balanced low sodium diet also i would suggest him to continue taking pantoprazole along with the tablet and also take gelusil syrup 10ml twice daily for heartburn Hope it clarifies and helps Followup if needed Good day.