Hi, Thanks for writing in. Anaplastic astrocytomas (WHO grade III) constitute about 10% of all gliomas. Definitive data on predictive and prognostic factors are lacking for these neoplasms that are considered the most enigmatic entity among the whole spectrum of astrocytic tumors because of their unclear biologic behavior and variable clinical outcome. Cancer is a difficult condition to treat and the progress of disease can be predicted only after initiation of treatment and response. Anaplastic astrocytoma is more on the aggressive side and shows behavior that requires a close watch. As there is only a small part showing anaplastic features, the cancer can still be controlled and aggressive treatment must be given in the beginning. In a cancer lesion having both aggressive and low grade areas, the tumor must be treated as an aggressive one and measures should be put in place to control tumor growth and control cellular proliferation. The age-standardized 5-year relative survival rate is 23.6%.