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What is Factor V mutation and does it create problems during pregnancy ?

Cuold you tell me About Factor V mutation of the blood and is there a issue when pregnant ? What should I know about this condition?
Asked On : Thu, 4 Aug 2011
Answers:  2 Views:  65
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  User's Response
hi brian,
welcome to hcm.factor v mutation leads to hypercoagubility disorder.normally factor v helps factor x to activate enzyme called thrombin which turn to fibrin help in clot.mutation leads to excessive clotting.and it may cause deev vein thrombosis,if clot goes to heart and lung produce stroke and pulmonary pregnancy it may leads to miscarriage,or still birth.its treatment vit k and frsh frozen plasma but better you concern any hematologist for that.
Answered: Thu, 4 Aug 2011
General & Family Physician Dr. Tina Jacob Das's  Response
Hello Brian
Welcome to HealthcareMagic.Factor V leiden, is a specific gene mutation which leads to a kind of bleeding disorder-where there is an increased risk of pathological clots obstructing the blood vessels(thrombophilia).These clots can be formed anywhere blocking the vessels in any organ including brain,liver , kidney.This abnormality needs special attention in women who are pregnant.In such cases there are increased risk of miscarriage/ loss of pregnancy. This risk is two-three times during the second or third trimester. Also it is seen to increase the risk of pregnancy induced hypertension, placental abruption(early separation of placenta), a delayed fetal growth.Howsoever, it must be comforting enough to know that these kind of women do have normal pregnancies also. So if you are in doubt, please do not panic, and with the help of your physician, consult a hematologist, who would guide you with a battery of tests.Wish you a good health .Take care.
Answered: Thu, 25 Aug 2011
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