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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Does Low Beta HCG Level Post IVF Indicate?

I am under IVF w/ ICSI Fertility treatment. I had 3 PGD tested Normal embryos. I had done 1 FET transfer of 5AA embryo which resulted in Negative Pregnancy with HCG level was less than 1. After a gap of 1 month I again went through a FET cycle in which I have transferred 2 6BB PGD tested embryos. Following is my timeline 9 Oct - took 10,000 unit of HCG 16 Oct - Transferred 2 6BB embryos 19 Oct - Progesterone Level is 36 22 OCT - Spotting # 1(pinkish - for couple of hours) 24 OCT - Spotting # 2(pinkish - for couple of hours) 25 Oct - Beta 1 testing - 11.7 HCG & Progesterone 39 my BETA 2 test is scheduled for 10/27 - Can this be a chemical pregnancy and is there still a chance of twins even though HCG level was low with BETA 1 test.
Mon, 25 Apr 2016
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Infertility Specialist,  's  Response
Hello, thanks for the query. Any pregnancy detected by doing beta hcg but not evident on scan is biochemical pregnancy. Yes, this could be a chemical pregnancy as you mentioned. The likelihood of continuation of pregnancy depends on the serial nearly doubling values of beta hcg every 48 hours rather than a single value. Having said that beta hcg of about 11.7 is interpreted as a low value to expect a marked rise on the next testing and to witness a clinical pregnancy except in extremely rare situations. But clinicians do want to wait and see to give it a benefit of doubt. Hope your concern is addressed satisfactorily. Take care.
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What Does Low Beta HCG Level Post IVF Indicate?

Hello, thanks for the query. Any pregnancy detected by doing beta hcg but not evident on scan is biochemical pregnancy. Yes, this could be a chemical pregnancy as you mentioned. The likelihood of continuation of pregnancy depends on the serial nearly doubling values of beta hcg every 48 hours rather than a single value. Having said that beta hcg of about 11.7 is interpreted as a low value to expect a marked rise on the next testing and to witness a clinical pregnancy except in extremely rare situations. But clinicians do want to wait and see to give it a benefit of doubt. Hope your concern is addressed satisfactorily. Take care.