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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Thrombocytopenia And Elevated Bilirubin Levels While Having Gilbert S Syndrome?

I am 28 years old student, I am suffering from Gilbert jaundice from last 4 years. could you please tell me what is the reference bilirubin count for that kind of jaundice. and last two weeks back i suffered from dengue fever and platelet counts are reduced drastically. reports for two weeks back : Platelet count 20000 bilirubin 6.6 and all other liver enzymes are high Now fever is cleared, platelet count is 1.8 lakhs and bilirubin is 3.2 and all liver enzymes are with in range. please advice about my diet (what all can I eat and what should I avoid eating) and also when can I resume my physical exercise and running. Is there any medical cure for Gilbert
Tue, 28 Feb 2017
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General & Family Physician 's  Response
People with GS predominantly have elevated unconjugated bilirubin, while conjugated bilirubin is usually within the normal range and is less than 20% of the total. Levels of bilirubin in GS patients are reported to be from 20 μM to 90 μM (1.2 to 5.3 mg/dl)] compared to the normal amount of

The level of total bilirubin is often further increased if the blood sample is taken after fasting for two days, and a fast can, therefore, be useful diagnostically.
carbamazepine and phenobarbital can reduce unconjugated bilirubin levels and may relieve other associated symptoms of Gilbert's syndrome
Eat plentiful amounts of raw fruits and vegetables, especially dark green leafy vegetables and orange, yellow, purple and red colored fruits and vegetables. Thirty to forty percent of the diet should consist of raw fruits and vegetables. Try to eat some raw fruits or vegetables with EVERY meal as they contain living enzymes, vitamin C, natural antibiotic substances and anti-cancer phytonutrients.
Avoid the fats that present a high workload for the liver and gall bladder. These are full-cream dairy products, margarines, processed vegetable oils (hydrogenated fats), deep fried foods, foods that are not fresh and contain rancid fats, preserved meats, animal skins and fatty meats. In those with a dysfunctional liver, I recommend avoiding all animal milks and substituting them with oat, rice, almond or soymilks. Eat the “good fats” which contain essential fatty acids in their natural unprocessed form.

These are found in cold pressed vegetable and seed oils, avocados, fish (especially oily fish such as salmon, tuna, sardines, herring, sablefish, flounder, trout, bass and mackerel), shrimp, prawns and crayfish, raw fresh nuts, raw fresh seeds such as flaxseeds (linseeds), sunflower seeds, safflower seeds, sesame seeds, hemp seeds, alfalfa seeds, pumpkin seeds and legumes (beans, peas and lentils). Seeds such as flaxseeds can be ground freshly everyday (in a regular coffee grinder or food processor) and can be added to cereals, smoothies, fruit salads and vegetables. Spirulina, evening primrose oil, black currant seed oil, borage oil and lecithin also contain healthy oils to help the liver. Do not use butter and/or margarine on your breads and crackers. Replace them with tahini, humus, pesto, tomato paste or relish, freshly minced garlic and cold pressed oil (chilli or other natural spices can be added if enjoyed), nut-spreads, fresh avocado, cold pressed olive oil or honey. The good fats are essential to build healthy cell membranes around the liver cells. As we get older we need to “oil” our bodies and not “grease” our bodies.

Think Natural
Avoid artificial chemicals and toxins such as insecticides, pesticides, and artificial sweeteners and colorings, (especially aspartame), flavorings and preservatives. Excess alcohol, particularly spirits, should be avoided.

Be Diverse
Consume a diverse range of proteins from grains, raw nuts, seeds, legumes, eggs, seafood, and if desired, free range chicken (without the skin), and lean fresh red meats. If you do not want to eat red meat or poultry this is quite acceptable as there are many other sources of protein. It is safe to be a strict vegetarian, however you may need to take supplements of vitamin B 12, iron, taurine and carnitine to avoid poor metabolism and fatigue. To obtain first class protein, strict vegetarians need to combine 3 of the following 4 food classes at one meal – grains, nuts, seeds and legumes, otherwise valuable essential amino acids may be deficient. If your body is lacking amino acids you will be fatigued and you may suffer with mood changes, reduced cognitive function, hypoglycaemia, poor immune and liver function and hair loss. I have met many strict vegans who felt unwell because they were lacking amino acids, iron and vitamin B 12, and after supplementing with these nutrients and modifying their diets they quickly regained excellent health.

Let Food Be Your Medicine
Many diseases can be overcome by eating healing foods that contain powerful medicinal properties. Optimal health and the prevention of disease is only possible by including these healing foods regularly in the diet. The healing substances found in certain foods or therapeutically active chemicals are known as phytochemicals. The culinary habits of different cultures have been recognised for decades as being influential in the incidence of diseases. Mediterranean countries have a lower prevalence of cardiovascular diseases because of the protective effect of traditional Mediterranean foods, such as olive oil, tomatoes and legumes. Broccoli and other vegetables in the cruciferous family are known to reduce the risk of bowel cancer, but it is only recently that scientists have isolated the phytochemicals which confer this protection. Broccoli has been found to contain a phytochemical called sulphoraphane, which enhances the phase two-detoxification pathway in the liver.

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What Causes Thrombocytopenia And Elevated Bilirubin Levels While Having Gilbert S Syndrome?

People with GS predominantly have elevated unconjugated bilirubin, while conjugated bilirubin is usually within the normal range and is less than 20% of the total. Levels of bilirubin in GS patients are reported to be from 20 μM to 90 μM (1.2 to 5.3 mg/dl)] compared to the normal amount of The level of total bilirubin is often further increased if the blood sample is taken after fasting for two days, and a fast can, therefore, be useful diagnostically. carbamazepine and phenobarbital can reduce unconjugated bilirubin levels and may relieve other associated symptoms of Gilbert s syndrome Eat plentiful amounts of raw fruits and vegetables, especially dark green leafy vegetables and orange, yellow, purple and red colored fruits and vegetables. Thirty to forty percent of the diet should consist of raw fruits and vegetables. Try to eat some raw fruits or vegetables with EVERY meal as they contain living enzymes, vitamin C, natural antibiotic substances and anti-cancer phytonutrients. Avoid the fats that present a high workload for the liver and gall bladder. These are full-cream dairy products, margarines, processed vegetable oils (hydrogenated fats), deep fried foods, foods that are not fresh and contain rancid fats, preserved meats, animal skins and fatty meats. In those with a dysfunctional liver, I recommend avoiding all animal milks and substituting them with oat, rice, almond or soymilks. Eat the “good fats” which contain essential fatty acids in their natural unprocessed form. These are found in cold pressed vegetable and seed oils, avocados, fish (especially oily fish such as salmon, tuna, sardines, herring, sablefish, flounder, trout, bass and mackerel), shrimp, prawns and crayfish, raw fresh nuts, raw fresh seeds such as flaxseeds (linseeds), sunflower seeds, safflower seeds, sesame seeds, hemp seeds, alfalfa seeds, pumpkin seeds and legumes (beans, peas and lentils). Seeds such as flaxseeds can be ground freshly everyday (in a regular coffee grinder or food processor) and can be added to cereals, smoothies, fruit salads and vegetables. Spirulina, evening primrose oil, black currant seed oil, borage oil and lecithin also contain healthy oils to help the liver. Do not use butter and/or margarine on your breads and crackers. Replace them with tahini, humus, pesto, tomato paste or relish, freshly minced garlic and cold pressed oil (chilli or other natural spices can be added if enjoyed), nut-spreads, fresh avocado, cold pressed olive oil or honey. The good fats are essential to build healthy cell membranes around the liver cells. As we get older we need to “oil” our bodies and not “grease” our bodies. Think Natural Avoid artificial chemicals and toxins such as insecticides, pesticides, and artificial sweeteners and colorings, (especially aspartame), flavorings and preservatives. Excess alcohol, particularly spirits, should be avoided. Be Diverse Consume a diverse range of proteins from grains, raw nuts, seeds, legumes, eggs, seafood, and if desired, free range chicken (without the skin), and lean fresh red meats. If you do not want to eat red meat or poultry this is quite acceptable as there are many other sources of protein. It is safe to be a strict vegetarian, however you may need to take supplements of vitamin B 12, iron, taurine and carnitine to avoid poor metabolism and fatigue. To obtain first class protein, strict vegetarians need to combine 3 of the following 4 food classes at one meal – grains, nuts, seeds and legumes, otherwise valuable essential amino acids may be deficient. If your body is lacking amino acids you will be fatigued and you may suffer with mood changes, reduced cognitive function, hypoglycaemia, poor immune and liver function and hair loss. I have met many strict vegans who felt unwell because they were lacking amino acids, iron and vitamin B 12, and after supplementing with these nutrients and modifying their diets they quickly regained excellent health. Let Food Be Your Medicine Many diseases can be overcome by eating healing foods that contain powerful medicinal properties. Optimal health and the prevention of disease is only possible by including these healing foods regularly in the diet. The healing substances found in certain foods or therapeutically active chemicals are known as phytochemicals. The culinary habits of different cultures have been recognised for decades as being influential in the incidence of diseases. Mediterranean countries have a lower prevalence of cardiovascular diseases because of the protective effect of traditional Mediterranean foods, such as olive oil, tomatoes and legumes. Broccoli and other vegetables in the cruciferous family are known to reduce the risk of bowel cancer, but it is only recently that scientists have isolated the phytochemicals which confer this protection. Broccoli has been found to contain a phytochemical called sulphoraphane, which enhances the phase two-detoxification pathway in the liver.