Hello, Taking Benadryl, an antihistamine, will help control inflammation and reduce swelling. A topical variety can be applied directly to the lips. Try to figure out what triggered this reaction. Possiilities include an allergic reation to food or liquids, a reaction to a new dental or cosmetic product, medications and exposure to chemicals, plants or a bug bite. Remove any irritants and stop using any new products. Think of dietary changes that may contribute. Stay well hydrated. Any severe change in your condition especially with an increase in swelling will require the care of a professional. Check your teeth for any signs of infection. Is there swelling close to a particular tooth? Pain, hot or pressure sensitivity? Ths may indicate an active infection and will require an antibiotic. See your dentist for a diagnosis and treatment recommendations. Keep taking anti-inflammatory medication. Tylenol and Motrin are additional medications to help limit the discomfort from inflammation. Some viral, bacterial or fungal infections may cause changes in your tissue that can be accompanied with swelling. Your dentist would prescribe medications for the particular diagnosed tissue condition if necessary. Thank you for your inquiry. I am available to assist you further if you have any additional questions or details to share.