My name is Anita. I was diagnosed with Overlap Connective Syndrome. I currently taking plaquenil and prednisone I do feel a lot better. The only problem is that I have some rash on both of my calves. Don t itch or burn but I was wondering if it was a side effect from medication. I am walking in the afternoon, which in South Texas the sun is still very bright around the time I walk. Not sure if my rash is from the sun or meds??