HI, Thanks for the query I understand your concern. The menstrual pain is due to strong contractions of uterine musculature ,,, so as to squeeze out the blood / It can be due to pin point cervix / Pelvic congestion. Panadol is a paracetamol based pain medicine & Ponston is non steroidal anti inflammatory drug. You can take either of them which ever is useful ... can be taken twice a day after food ( 12 hourly ) Combining both may cause acidity. To have better effect - - take rest. - Try sleeping over abdomen / hot fomentation or light abdominal massage. - Avoid excessive caffeine, alcohol or tobacco. - tab. Dysmen ( mefenemic & dicyclomine HCL combination ) over the counter twice a day after food, -doing regular exercises reduce the pain gradually. - If there is no relief.. visit a gynecologist for further advise -after first child birth the pain vanishes completely Thanks