Hello, When considering medication, please look closely at your labels to see active ingredients. Many brand names have combinations to treat multiple symptoms. This can lead to excess dosage of medications. Tylenol or acetaminophen is often found in many over the counter medications. Excess medication can damage tissue such as the liver or change the effectiveness or recommended use for the particular medication. How did you irritate your sinus? Nasal sprays that contain oxymetaxoline HCI are very effective at reducing sinus pressure. If your delicate nasal tissue is dry or sore, saline nasal spray may be a better choice. An humidifier or steam relief may make you feel better. Avoid any irritants and realize tissue needs time to heal. The effects of the antihistamine Benadryl can be beneficial for irritating allergic type reactions. There are a number of medications that you can try, but you need to give some time for them to work. Tylenol PM is a formulation that combines acetaminophen and Benedryl at the proper combination to avoid liver damage. This will make you drowsy and can help you sleep. Mucinex DM can be taken with Benedryl, but avoid with Afrin. Plain Mucinex can be taken with Afrin. Drink plenty of water with all Mucinex products. Your other medical concerns need to be considered. High blood pressure or heart conditions can affect choices and recommendations. Thank you for your inquiry.