hi, thank-you for providing the brief history of you. As to know that what is panhypopituitarism is the below mentioned will help you understand. Background The pituitary gland is called the master endocrine gland of the body because it controls the function of other endocrine organs. The anterior pituitary produces the hormones thyrotropin (thyroid-stimulating hormone [TSH]), corticotropin (adrenocorticotropic hormone [ACTH]), luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), and prolactin (PRL). The anterior pituitary is controlled by specific hypothalamic-releasing hormones. The posterior pituitary produces vasopressin (antidiuretic hormone [ADH]) and oxytocin. Panhypopituitarism is a condition of inadequate or absent production of the anterior pituitary hormones. It is frequently the result of other problems that affect the pituitary gland and either reduce or destroy its function or interfere with hypothalamic secretion of the varying pituitary-releasing hormones. Panhypopituitarism can be the end result of various clinical scenarios. The signs and symptoms are diverse. Since the pituitary gland is the main of all, any abnormality in that can lead to various issues including the growth hormone. Consulting a physician can help further into the depth of the situation. Also, fatigue is common due to disturbed metabolism and may lead to muscle & joint aches and pains. Undergoing physical therapy will help imporve the metabolism & immune system. Regards Jay Indravadan Patel