Hi there, The most common cause of having bumps that are painful after injecting anything is an infection. Sometimes, this is self limiting and will resolve, and other times this will need treatment with antibiotics and possibly even a drainage if it forms an abscess. The symptoms of puffiness, redness, pain, and feeling that you want to gouge them out is classic of an abscess (think of this as a very large pimple under your skin). I would do warm compresses to the affected area, as warm as you can stand it for as long as you can. I d say 20 minutes with very warm compress, off for 10 minutes, then on again. This may cause the bumps to start to drain pus, which is a good thing. If they continue to enlarge and be painful, you ll likely need to see a doctor for some antibiotics, and possibly even an incision and drainage procedure, where the doctor takes a knife and opens them up. I d start with the warm compresses and see how you do. The fact that you re having fevers is worrisome that the infection may be in your blood and causing problems. If you continue to have fevers, chills, or any other symptoms that persist, I would definitely see a doctor and have them check blood cultures. I would also get checked for HIV, Hepatitis B and C, and if you do have bacteria in blood that persists, you need to have an ultrasound of the valves in your heart, as sometimes the bacteria from injecting can travel to those valves and cause damage. This usually requires treatment with a long course of antibiotics, and can cause continuing problems if not treated. I wouldn t beat yourself up for shooting meth. We all struggle with addictive problems. Some people use drugs, some people overeat, and some take it out on their loved ones. Those who judge you are simply hiding their own problems or are in denial. I would ask you to remember there are people who love you, and even though I have never met you or talked to you in person, I feel for you and I understand what you are going through. You are still a valuable person, and please don t ever feel down about yourself. I hope this is helpful. Please feel free to reach out to me if you need help in anyway, even if it is non-medical.