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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes High ALP Levels?

4 months ago my alp came back at 140,last week it was 945.The doctor did an ERCP and found no stones but the bile duct was 2 times normal size. I had bloodwork done 2 days after and my alp is now 1180,I don t see him until next week. Any ideas what the cause could be?
Fri, 19 Feb 2016
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General & Family Physician 's  Response
Hi thanks for asking question.
Elevated alp doesn't always mean cholestatic jaundice.
It may get elevated in pregnancy, hormones use, bone disease,cancer, leukemoid reaction ,amyloidosis, connective tissue disease etc.
Your alp count decreasing so mostly leukemoid reaction or infection might be the cause.regularly follow up needed.
If any other related sign present like bone pain, weight loss etc then physical examination done and accordingly investigated.
I hope you understand my concern.
Wish you good health
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What Causes High ALP Levels?

Hi thanks for asking question. Elevated alp doesn t always mean cholestatic jaundice. It may get elevated in pregnancy, hormones use, bone disease,cancer, leukemoid reaction ,amyloidosis, connective tissue disease etc. Your alp count decreasing so mostly leukemoid reaction or infection might be the cause.regularly follow up needed. If any other related sign present like bone pain, weight loss etc then physical examination done and accordingly investigated. I hope you understand my concern. Wish you good health