hi dear welcome to HealthCareMagic. thanks for trusting us. I have gone through your questions and understood your concerns. Verapamil is calcium channel blocker, used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. it has side effects such as constipation, headache, dizziness, stuffy nose, sinus pain, sore throat, asthenia (muscle weakness), muscle ache, cramps, pain and stiffness, slow heartbeat. Triamterene is a potassium-sparing diuretic to treat fluid retention (edema). You should not use it if you have severe kidney or liver disease, urination problems. most common side effects are dizziness, hypotension, lightheadedness, tiredness and weakness, headache, stomach discomfort, or diarrhea. Aspirin is an antiplatelet agents, has several side effects in GI discomfort, ulcer or bleeding, nausea, vomiting, rash, edema, etc Estrogen has side effects such as abdominal pain, headache, nausea, muscle pain, diarrhea, etc. testosterone has side effects such as acne, anxiety, weakness, headache, breast soreness, hypertension and many more. the interaction that could be found among the medicines you used are: 1. triamterene & verapamil has minor effect where triamterene will increase the level of verapamil, cause kidney problem. 2. verapamil & estrogen; verapamil will increase the level of estrogen. 3. verapamil & aspirin; verapamil increases effect of aspirin, enhance antiplatelet activity 4. triamterene & aspirin; both increase potassium serum in body, increase the risk of acute renal failure. should be monitored closely. the constant pain in hands that you have may be the effect of using verapamil or caused by the interactions of some drugs you have consumed. if this persists or worsen, please meet your local doctor and describe your complaint and all the medicine you have. maybe you need some dosage adjustment. I hope these can be helpful to clarify your queries. if you have another thing to be discussed, feel free to ask me in HCM. wish you have a good health always. take care Regards, dr. Asti Yuliadha