I have been taking Metformin for almost a year without much problem but about 5 months ago my doctor also gave me Zetia to take, At first i would only have a problem with diarreha ocasionally but now it s to the point that I am afraid to go somewhere in the early part of the day because when it comes it comes on strongly with no holding for a second, and it is very embarassing. I still work full time and would like to be active to lose some weight but the more I move around the more problem it can be. Can it be the combination of these two drugs or do you think it s something else. I am tired of living on anti-diarreha medicine.