I m a 35 yr. female. I don t have any health problems. I have been on Depo for 18 years. For the past 11 days I have had cramps move into different parts of my body for no reason. It started in my right nipple, traveled into right quad, then up into my right side, lower stomach, then into my knees. I thought it was bad cramps. Now, I have a thumping sound in my right ear. It started 30 minutes ago.