My friend is in end of life stage with liver cancer. She was on diluadid in the hospital and she was good she dosed off but was coherent when she was awake. Now that we have brought her home they sent her with Oxycodone IR 80 mg and she immediately became a mental mess. She mumbles and is trying to pick up things that are not there and she can not answer anything. She is also on Morphine liquid and is to take a .25 on the syringe if she has pain in between the 4hr intervals of oxycodone. Anyway, I acted on my belief that she is over medicated or having a very bad reaction to oxycodone. Last night I did not give her the oxycodone but only gave her the morphine and gave it to her every 4 hrs. Before the 3rd dose would have been due it was like she woke up, she got out of bed went to the kitchen got something to drink and gave me very sensible intructions on what she wanted from the store. She has not been eating or drinking anything for a week and if she went to the bathroom it would take at least on hour just to get her down the hall because she would stop and try to pick up stuff that was not there. She made absolutely no sense at all. She couldn t hold a glass or eat. I asked her several times if she was in pain and she clearly replied no she was ok. So when her oxycodone was due again I gave it to her instead of morphine and she was once again out of her mind and not in this world. I do not want my friend in pain at all and I do understand that at this point, the point is to just make sure she is pain free. I want her pain free. I am aware that she will not be able to communicate before this is all over but I do not think this is the time. So, my question is what would cause her to have such a bad reaction to the oxycodone? Is it because her liver is not working right ? if that is it why don t the morphine mess her up like that? I just really believe she would not want to spend her last few months incapacitated if she didn t have to be. Please help me understand so maybe I can help her family to see she is not at that point yet.