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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Symptoms Of P-anca?

I am a health care provider and would like to know more about P-ANCA. I found out what the initials

stand for, know that it can cause kidney failure and

pulmonary hemorrhaging, know the treatment is

large doses of steroids and chemotherapy, as well

as hemodialysis and plasmapharesis. What causes

it? Is it considered an autoimmune disease?

What is the prognosis?

thanks
Mon, 12 Jan 2015
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General & Family Physician,  's  Response
Hi. p ANCA stands for perinuclear antineutrophil cytoplasmic antibodies. The major target of pANCA is the enzyme myeloperoxidase.
p ANCA have been reported to occur in microscopic polyangitis churg strauss syndrome crescentric glomerulonephritis and wegeners granulomatosis.
All there diseases are types of vasculitis. 90% of wegeners granulomatosis have cytoplasmic ANCA. These diseases are not autoimmune but autoinflammatory type of disease. After giving treatment daily oral cyclophosphamide and glucocorticoids, they have a good prognosis.
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What Are The Symptoms Of P-anca?

Hi. p ANCA stands for perinuclear antineutrophil cytoplasmic antibodies. The major target of pANCA is the enzyme myeloperoxidase. p ANCA have been reported to occur in microscopic polyangitis churg strauss syndrome crescentric glomerulonephritis and wegeners granulomatosis. All there diseases are types of vasculitis. 90% of wegeners granulomatosis have cytoplasmic ANCA. These diseases are not autoimmune but autoinflammatory type of disease. After giving treatment daily oral cyclophosphamide and glucocorticoids, they have a good prognosis.