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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Side Effects Of Diabetes Drugs?

is it possible that the recent surge in type 2 diabetes has been caused by medications that have been prescribed through the past decade or so that may have had an adverse effect on the liver, kidneys, and or pancreas, and if so, which medications would be the most harmful ??
Thu, 21 May 2015
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Internal Medicine Specialist 's  Response
Hello,

this is not very likely to happen but I'll give you some insight!
There are certain drugs that may worsen glucose control in diabetic and pre-diabetic patients. Please note that no drug may cause diabetes, except those that may destroy the pancreas (side effect). The drugs only worsen glucose control. If one's body is able to cope efficiently with the glucose load then one's not going to develop diabetes no matter what drug one uses.

Statins are well-known for causing a higher than usual blood glucose. Some more than others. Pitavastatin is supposed to be the exception.

Diuretics may also worsen diabetes control.

Corticosteroids may cause higher blood glucose even in the absence of diabetes or pre-diabetes.

And there are other drugs (less commonly used) that may also cause it like pentamidine for example. Pentamidine may cause pancreatic damage and persistent hyperglycemia.

Regarding drugs for diabetes, the only real concern is about the drugs that may cause pancreatitis like the GLP-1 agonists and the DPP4 inhibitors.

Your question was not very clear, so I hope I've addressed all the issues. It wasn't clear to me whether you wanted information about diabetes medications or medications in general. I believe it's the latter, so I answered accordingly.

Kind Regards!
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What Are The Side Effects Of Diabetes Drugs?

Hello, this is not very likely to happen but I ll give you some insight! There are certain drugs that may worsen glucose control in diabetic and pre-diabetic patients. Please note that no drug may cause diabetes, except those that may destroy the pancreas (side effect). The drugs only worsen glucose control. If one s body is able to cope efficiently with the glucose load then one s not going to develop diabetes no matter what drug one uses. Statins are well-known for causing a higher than usual blood glucose. Some more than others. Pitavastatin is supposed to be the exception. Diuretics may also worsen diabetes control. Corticosteroids may cause higher blood glucose even in the absence of diabetes or pre-diabetes. And there are other drugs (less commonly used) that may also cause it like pentamidine for example. Pentamidine may cause pancreatic damage and persistent hyperglycemia. Regarding drugs for diabetes, the only real concern is about the drugs that may cause pancreatitis like the GLP-1 agonists and the DPP4 inhibitors. Your question was not very clear, so I hope I ve addressed all the issues. It wasn t clear to me whether you wanted information about diabetes medications or medications in general. I believe it s the latter, so I answered accordingly. Kind Regards!